Anticancer Mechanisms and Potential Anticancer Applications of Antimicrobial Peptides and Their Nano Agents

Traditional chemotherapy is one of the main methods of cancer treatment, which is largely limited by severe side effects and frequent development of multi-drug resistance by cancer cells. Antimicrobial peptides (AMPs) with high efficiency and low toxicity, as one of the most promising new drugs to r...

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Bibliographic Details
Published in:International journal of nanomedicine 2024-01, Vol.19, p.1017-1039
Main Authors: Dong, Ziyi, Zhang, Xinyu, Zhang, Qing, Tangthianchaichana, Jakkree, Guo, Mingxue, Du, Shouying, Lu, Yang
Format: Article
Language:English
Subjects:
Amino acids
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
anticancer application
anticancer mechanisms
Antimicrobial Cationic Peptides - pharmacology
Antimicrobial Peptides
Cancer
Chemotherapy
drug combination
Drug resistance
Drug therapy
Drug therapy, Combination
Humans
Neoplasms - drug therapy
peptide nano agents
Peptides
Review
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Summary:Traditional chemotherapy is one of the main methods of cancer treatment, which is largely limited by severe side effects and frequent development of multi-drug resistance by cancer cells. Antimicrobial peptides (AMPs) with high efficiency and low toxicity, as one of the most promising new drugs to replace chemoradiotherapy, have become a current research hotspot, attracting the attention of worldwide researchers. AMPs are natural-source small peptides from the innate immune system, and certain AMPs can selectively kill a broad spectrum of cancer cells while exhibiting less damage to normal cells. Although it involves intracellular mechanisms, AMPs exert their anti-cancer effects mainly through membrane destruction effect; thus, AMPs also hold unique advantages in fighting drug-resistant cancer cells. However, the poor stability and hemolytic toxicity of peptides limit their clinical application. Fortunately, functionalized nanoparticles have many possibilities in overcoming the shortcomings of AMPs, which provides a huge prospect for better application of AMPs. In this paper, we briefly introduce the characteristics and different sources of AMPs, review and summarize the mechanisms of action and the research status of AMPs used as an anticancer therapy, and finally focus on the further use of AMPs nano agents in the anti-cancer direction.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S445333