Function, Regulation and Biological Roles of PI3Kγ Variants

Phosphatidylinositide 3-kinase (PI3K) γ is the only class IB PI3K member playing significant roles in the G-protein-dependent regulation of cell signaling in health and disease. Originally found in the immune system, increasing evidence suggest a wide array of functions in the whole organism. PI3Kγ...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2019-08, Vol.9 (9), p.427
Main Authors: Nürnberg, Bernd, Beer-Hammer, Sandra
Format: Article
Language:English
Subjects:
class I PI3-kinases
G-proteins
Gβγ
p110γ
p87 (p84)
PI3K (phosphatidylinositide 3-kinase)
Ras
Review
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Summary:Phosphatidylinositide 3-kinase (PI3K) γ is the only class IB PI3K member playing significant roles in the G-protein-dependent regulation of cell signaling in health and disease. Originally found in the immune system, increasing evidence suggest a wide array of functions in the whole organism. PI3Kγ occur as two different heterodimeric variants: PI3Kγ (p87) and PI3Kγ (p101), which share the same p110γ catalytic subunit but differ in their associated non-catalytic subunit. Here we concentrate on specific PI3Kγ features including its regulation and biological functions. In particular, the roles of its non-catalytic subunits serving as the main regulators determining specificity of class IB PI3Kγ enzymes are highlighted.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom9090427