A Case of Autoimmune Hemolytic Anemia after the First Dose of COVID-19 mRNA-1273 Vaccine with Undetected Pernicious Anemia

By this time, multiple vaccines have been approved to limit the spread of SARS-CoV-2 worldwide. These include new-generation vaccines that contain mRNA of the target organism. Some common side effects were identified and reported during phase 3 clinical trials of vaccination, but more rare adverse e...

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Bibliographic Details
Published in:Case reports in hematology 2022-01, Vol.2022, p.2036460-5
Main Authors: Jaydev, Fnu, Kumar, Vinod, Khatri, Jaikumar, Shahani, Shobha, Beganovic, Sead
Format: Article
Language:English
Subjects:
Anemia
Antibodies
B cells
Case Report
Case reports
Complications and side effects
Coronaviruses
COVID-19 vaccines
Hemoglobin
Hemolytic anemia
Iron
Laboratories
Messenger RNA
Neutrophils
Patients
Severe acute respiratory syndrome coronavirus 2
Sign language
Steroids
Thrombosis
Vaccination
Vaccines
Viral antigens
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Summary:By this time, multiple vaccines have been approved to limit the spread of SARS-CoV-2 worldwide. These include new-generation vaccines that contain mRNA of the target organism. Some common side effects were identified and reported during phase 3 clinical trials of vaccination, but more rare adverse events were reported in the literature. One such concern is autoimmune conditions that SARS-CoV-2 viral antigens could have possibly incited. We are presenting here a case of a young female with no known autoimmune diseases, diagnosed with autoimmune hemolytic anemia about a week after receiving her first dose of the COVID-19 mRNA vaccine. We discuss the possible culprit for precipitation of autoimmune hemolytic anemia after the SARS-CoV-2 mRNA vaccine, which encodes virus spike protein. This case highlights the importance of being vigilant for identifying rare adverse events that could appear during mass vaccination.
ISSN:2090-6560
2090-6579
DOI:10.1155/2022/2036460