Seroepidemiological Survey of Chronic Chagas Disease in a Rural Community in Southern Bahia, Brazil, Using Recombinant Chimeric Antigens

• Published in: Pathogens (Basel) 2023-10, Vol.12 (10), p.1222
• Main Authors: Soares, Neci Matos, Barreto, Nilo Manoel Pereira Vieira, Farias, Marina Morena Brito, de Lima Oliveira, Cíntia, Araújo, Weslei Almeida Costa, de Souza, Joelma Nascimento, Teixeira, Márcia Cristina Aquino, Gonçalves, Noilson Lázaro Sousa, Sampaio, Daniel Dias, Pavan, Tycha Bianca Sabaini, Celedon, Paola Alejandra Fiorani, Zanchin, Nilson Ivo Tonin, Santos, Fred Luciano Neves
• Format: Article
• Language: English
• Subjects: active case finding; Antigens; Chagas disease; chronic chagas disease; Clay; Communication; Control programs; Diagnosis; Environmental factors; Health aspects; Health services; Immune system; Immunoglobulin G; Infections; Parasites; prevalence; Protozoa; Risk factors; Rural areas; Rural communities; Rural population; Rural populations; screening; Seroepidemiology; serologic diagnosis; Serology; Socioeconomics; Software; Statistics; Surveillance; Surveys; Testing; Tropical diseases; Trypanosoma cruzi; Variables; Vector-borne diseases
• ISSN: 2076-0817; 2076-0817
• DOI: 10.3390/pathogens12101222

Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is a neglected tropical disease with life-threatening implications. In this study, we conducted a seroepidemiological survey to determine the prevalence and clinical profiles of CD in 217 individuals from an impoverished rural community in Southern Bahia, Brazil. The overall prevalence of CD in the studied community was 0.92%, detected through latent class analysis (LCA). Two individuals tested positive for anti-T. cruzi IgG, both being male farmers. One case was a 22-year-old man born in Camamu, with no evidence of congenital transmission, suggesting other routes of transmission such as vector-borne transmission due to migratory activities. The other case was a 69-year-old man born in São Felipe, who had lived in an adobe/brick house and had a pacemaker due to cardiac involvement caused by CD. The prevalence in this community was lower than expected, given the socioeconomic conditions and environmental factors that contribute to T. cruzi transmission. This could be attributed to the implementation of preventive measures and vector control programs by the Brazilian Government. However, continuous monitoring and surveillance are essential to sustain control efforts and detect any potential re-emergence of the disease. While the overall prevalence was low, the detection of positive cases underscores the need for continued surveillance and control measures in vulnerable populations, such as rural communities. Active surveillance, early diagnosis, and timely treatment are crucial in preventing disease progression and complications, thereby enhancing the effectiveness of screening and treatment programs.