Characterization of Escherichia coli isolated from urinary tract infection and association between virulence expression and antimicrobial susceptibility

The capacity of antibiotics to modulate bacterial virulence has raised concerns over the appropriateness of antibiotic therapies, including when dosing strategies fall below sub-therapeutic levels. In this work, we investigated the ability of antibiotics to influence virulence in Escherichia coli is...

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Bibliographic Details
Published in:BMC microbiology 2022-04, Vol.22 (1), p.89-89, Article 89
Main Authors: Derakhshan, Safoura, Ahmadi, Sanaz, Ahmadi, Erfan, Nasseri, Sherko, Aghaei, Abbas
Format: Article
Language:English
Subjects:
Analysis
Animal models
Animals
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Bacterial infections
Ceftriaxone
Ceftriaxone - pharmacology
Ciprofloxacin
Ciprofloxacin - pharmacology
Control
Dosage and administration
E coli
Escherichia coli
Escherichia coli Infections - microbiology
Gene expression
Genetic susceptibility
Growth rate
Hemolysin
Hemolysis
Identification and classification
Infections
Investigations
Minimum inhibitory concentration
Pathogenesis
Pathogenicity
Phylogenetics
Prevention
Risk factors
Testing
Tetracycline
Tetracyclines
Urinary tract
Urinary tract infections
Urinary Tract Infections - microbiology
Urogenital system
Virulence
Virulence (Microbiology)
Virulence Factors - genetics
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Summary:The capacity of antibiotics to modulate bacterial virulence has raised concerns over the appropriateness of antibiotic therapies, including when dosing strategies fall below sub-therapeutic levels. In this work, we investigated the ability of antibiotics to influence virulence in Escherichia coli isolated from urinary tract infection (UTI). Out of 120 isolates, 32.5% carried pap, 21.7% carried hlyA, and 17.5% carried cnf. The predominant B2 phylogroup was significantly associated with the quinolone-resistant isolates. A significant association was seen between the presence of hlyA hemolysin and susceptibility to ceftriaxone and ciprofloxacin (P 
ISSN:1471-2180
1471-2180
DOI:10.1186/s12866-022-02506-0