Cordycepin exacerbates cadmium-induced neurotoxicity via promoting endoplasmic reticulum stress-associated apoptosis

[Display omitted] •Exposure of Cor deteriorated Cd-induced learning and memory deficits in mice.•Cor promoted Cd-induced neuronal apoptosis both in vivo and vitro.•The ER stress pathway was involved in the increased Cd- and Cor-induced neurotoxicity. Cordycepin (Cor) is a potent bioactive constituen...

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Published in:Journal of functional foods 2022-02, Vol.89, p.104935, Article 104935
Main Authors: Du, Ke, Zheng, Xi, Lv, Junya, Zhong, Xin, Wei, Minjie, Liu, Mingyan
Format: Article
Language:English
Subjects:
Apoptosis
Asia
Cadmium
cognitive disorders
Cordycepin
Cordyceps militaris
endoplasmic reticulum
Endoplasmic reticulum stress
Food safety
growth retardation
herbal medicines
Neurotoxicity
pollutants
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Summary:[Display omitted] •Exposure of Cor deteriorated Cd-induced learning and memory deficits in mice.•Cor promoted Cd-induced neuronal apoptosis both in vivo and vitro.•The ER stress pathway was involved in the increased Cd- and Cor-induced neurotoxicity. Cordycepin (Cor) is a potent bioactive constituent of Cordyceps militaris, which has been used as a daily tonic food and herbal medicine in Asia. Cadmium (Cd) is a widespread neurotoxic environmental contaminant, and it has been detected as a pollutant in Cordyceps militaris. However, the potential effects of Cor on Cd neurotoxicity remains unknown. This study aimed to investigate the effects and possible mechanisms of Cor on neurotoxicity in Cd-induced cell and preclinical models. It was observed that Cor administration aggravated Cd-induced cognitive impairment and neurotoxicity in mice, exerted synergistic growth inhibition, and promoted apoptosis of SH-SY5Y cells. These effects were found to be mediated through the activation of endoplasmic reticulum (ER) stress. Overall, our findings suggest that Cor can increase Cd-induced neurotoxicity via promoting ER stress-associated apoptosis. These observations may support the implementation of stricter criterion for the detection of Cd in Cordyceps militaris, to keep the consumers safe.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2022.104935