The role of Ca2+ signaling in Parkinson's disease

Across all kingdoms in the tree of life, calcium (Ca2+) is an essential element used by cells to respond and adapt to constantly changing environments. In multicellular organisms, it plays fundamental roles during fertilization, development and adulthood. The inability of cells to regulate Ca2+ can...

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Bibliographic Details
Published in:Disease models & mechanisms 2017-05, Vol.10 (5), p.519-535
Main Authors: Zaichick, Sofia V., McGrath, Kaitlyn M., Caraveo, Gabriela
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amyotrophic lateral sclerosis
Apoptosis
Calcium
Homeostasis
Mutation
Neurodegeneration
Parkinson's disease
Pathology
Plasma
Proteins
Review
Signal transduction
α-synuclein
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Summary:Across all kingdoms in the tree of life, calcium (Ca2+) is an essential element used by cells to respond and adapt to constantly changing environments. In multicellular organisms, it plays fundamental roles during fertilization, development and adulthood. The inability of cells to regulate Ca2+ can lead to pathological conditions that ultimately culminate in cell death. One such pathological condition is manifested in Parkinson's disease, the second most common neurological disorder in humans, which is characterized by the aggregation of the protein, α-synuclein. This Review discusses current evidence that implicates Ca2+ in the pathogenesis of Parkinson's disease. Understanding the mechanisms by which Ca2+ signaling contributes to the progression of this disease will be crucial for the development of effective therapies to combat this devastating neurological condition.
ISSN:1754-8403
1754-8411
DOI:10.1242/dmm.028738