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Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort
Air pollution exposure during pregnancy has been associated with adverse birth outcomes and health problems later in life. We investigated sex-specific transcriptomic responses to gestational long- and short-term exposure to particulate matter with a diameter
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| Published in: | Environmental health 2017-06, Vol.16 (1), p.52-52, Article 52 |
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| creator | Winckelmans, Ellen Vrijens, Karen Tsamou, Maria Janssen, Bram G Saenen, Nelly D Roels, Harry A Kleinjans, Jos Lefebvre, Wouter Vanpoucke, Charlotte de Kok, Theo M Nawrot, Tim S |
| description | Air pollution exposure during pregnancy has been associated with adverse birth outcomes and health problems later in life. We investigated sex-specific transcriptomic responses to gestational long- and short-term exposure to particulate matter with a diameter |
| doi_str_mv | 10.1186/s12940-017-0264-y |
| format | article |
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) in order to elucidate potential underlying mechanisms of action.
Whole genome gene expression was investigated in cord blood of 142 mother-newborn pairs that were enrolled in the ENVIRONAGE birth cohort. Daily PM
exposure levels were calculated for each mother's home address using a spatial-temporal interpolation model in combination with a dispersion model to estimate both long- (annual average before delivery) and short- (last month of pregnancy) term exposure. We explored the association between gene expression levels and PM
exposure, and identified modulated pathways by overrepresentation analysis and gene set enrichment analysis.
Some processes were altered in both sexes for long- (e.g. DNA damage) or short-term exposure (e.g. olfactory signaling). For long-term exposure in boys neurodevelopment and RhoA pathways were modulated, while in girls defensin expression was down-regulated. For short-term exposure we identified pathways related to synaptic transmission and mitochondrial function (boys) and immune response (girls).
This is the first whole genome gene expression study in cord blood to identify sex-specific pathways altered by PM
. The identified transcriptome pathways could provide new molecular insights as to the interaction pattern of early life PM
exposure with the biological development of the fetus.</description><identifier>ISSN: 1476-069X</identifier><identifier>EISSN: 1476-069X</identifier><identifier>DOI: 10.1186/s12940-017-0264-y</identifier><identifier>PMID: 28583124</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adolescent ; Adult ; Air Pollutants - analysis ; Air Pollutants - toxicity ; Air pollution ; Airborne particulates ; Alcohol ; Ambient air pollution ; Belgium ; Birth weight ; Cancer ; Childbirth & labor ; Cohort Studies ; Cord blood ; Damage ; Deoxyribonucleic acid ; DNA ; DNA damage ; DNA microarrays ; Education ; Environmental health ; Ethnicity ; Exposure ; Female ; Fetal ; Fetal Blood - chemistry ; Fetuses ; Gene expression ; Gene set enrichment analysis ; Genomes ; Girls ; Grandparents ; Health aspects ; Health problems ; Health risk assessment ; Humans ; Immune response ; Immune system ; Infant, Newborn ; Infants (Newborn) ; Interpolation ; Kinases ; Male ; Maternal Exposure ; Microarray analysis ; Mitochondria ; Mothers ; Neurodevelopment ; Outdoor air quality ; Parent educational background ; Particulate matter ; Particulate Matter - analysis ; Particulate Matter - toxicity ; Pregnancy ; RhoA protein ; Rope ; Sex ; Sex Factors ; Signatures ; Synaptic transmission ; Transcriptome - drug effects ; Young Adult</subject><ispartof>Environmental health, 2017-06, Vol.16 (1), p.52-52, Article 52</ispartof><rights>COPYRIGHT 2017 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2017</rights><rights>The Author(s). 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-b60a6e52a6789780eb6ec8087f4fbb6f1ec6ee99dad0145f9faa383d103ae0553</citedby><cites>FETCH-LOGICAL-c560t-b60a6e52a6789780eb6ec8087f4fbb6f1ec6ee99dad0145f9faa383d103ae0553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458481/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1915552959?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28583124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winckelmans, Ellen</creatorcontrib><creatorcontrib>Vrijens, Karen</creatorcontrib><creatorcontrib>Tsamou, Maria</creatorcontrib><creatorcontrib>Janssen, Bram G</creatorcontrib><creatorcontrib>Saenen, Nelly D</creatorcontrib><creatorcontrib>Roels, Harry A</creatorcontrib><creatorcontrib>Kleinjans, Jos</creatorcontrib><creatorcontrib>Lefebvre, Wouter</creatorcontrib><creatorcontrib>Vanpoucke, Charlotte</creatorcontrib><creatorcontrib>de Kok, Theo M</creatorcontrib><creatorcontrib>Nawrot, Tim S</creatorcontrib><title>Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort</title><title>Environmental health</title><addtitle>Environ Health</addtitle><description>Air pollution exposure during pregnancy has been associated with adverse birth outcomes and health problems later in life. We investigated sex-specific transcriptomic responses to gestational long- and short-term exposure to particulate matter with a diameter < 2.5 μm (PM
) in order to elucidate potential underlying mechanisms of action.
Whole genome gene expression was investigated in cord blood of 142 mother-newborn pairs that were enrolled in the ENVIRONAGE birth cohort. Daily PM
exposure levels were calculated for each mother's home address using a spatial-temporal interpolation model in combination with a dispersion model to estimate both long- (annual average before delivery) and short- (last month of pregnancy) term exposure. We explored the association between gene expression levels and PM
exposure, and identified modulated pathways by overrepresentation analysis and gene set enrichment analysis.
Some processes were altered in both sexes for long- (e.g. DNA damage) or short-term exposure (e.g. olfactory signaling). For long-term exposure in boys neurodevelopment and RhoA pathways were modulated, while in girls defensin expression was down-regulated. For short-term exposure we identified pathways related to synaptic transmission and mitochondrial function (boys) and immune response (girls).
This is the first whole genome gene expression study in cord blood to identify sex-specific pathways altered by PM
. The identified transcriptome pathways could provide new molecular insights as to the interaction pattern of early life PM
exposure with the biological development of the fetus.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Air Pollutants - analysis</subject><subject>Air Pollutants - toxicity</subject><subject>Air pollution</subject><subject>Airborne particulates</subject><subject>Alcohol</subject><subject>Ambient air pollution</subject><subject>Belgium</subject><subject>Birth weight</subject><subject>Cancer</subject><subject>Childbirth & labor</subject><subject>Cohort Studies</subject><subject>Cord blood</subject><subject>Damage</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA microarrays</subject><subject>Education</subject><subject>Environmental health</subject><subject>Ethnicity</subject><subject>Exposure</subject><subject>Female</subject><subject>Fetal</subject><subject>Fetal Blood - chemistry</subject><subject>Fetuses</subject><subject>Gene expression</subject><subject>Gene set enrichment analysis</subject><subject>Genomes</subject><subject>Girls</subject><subject>Grandparents</subject><subject>Health aspects</subject><subject>Health problems</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Infant, Newborn</subject><subject>Infants (Newborn)</subject><subject>Interpolation</subject><subject>Kinases</subject><subject>Male</subject><subject>Maternal Exposure</subject><subject>Microarray analysis</subject><subject>Mitochondria</subject><subject>Mothers</subject><subject>Neurodevelopment</subject><subject>Outdoor air quality</subject><subject>Parent educational background</subject><subject>Particulate matter</subject><subject>Particulate Matter - analysis</subject><subject>Particulate Matter - toxicity</subject><subject>Pregnancy</subject><subject>RhoA protein</subject><subject>Rope</subject><subject>Sex</subject><subject>Sex Factors</subject><subject>Signatures</subject><subject>Synaptic transmission</subject><subject>Transcriptome - drug effects</subject><subject>Young Adult</subject><issn>1476-069X</issn><issn>1476-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUkFvFCEYnRiNrdUf4MWQeOllKswAAx5MNs1aN2m2iVHjjTDMxyybGVhhVrtn_7isu9bWGA7A97334Ht5RfGS4AtCBH-TSCUpLjFpSlxxWu4eFaeENrzEXH59fO98UjxLaY0zUHD2tDipBBM1qehp8XMJP9oQPUpwW6YNGGedQVPUPpnoNlMYASXXez1tIySkfYd6SJOeXPB6QHC7CSl30BSQdR7QRsfJmQHS2_29c75PyMYwomkFaL78svh4s5xdzVHr4rRCJqxCnJ4XT6weErw47mfF5_fzT5cfyuubq8Xl7Lo0jOOpbDnWHFileSNkIzC0HIzAorHUti23BAwHkLLTHSaUWWm1rkXdEVxrwIzVZ8XioNsFvVab6EYddypop34XQuzV8fdKWMO1BsI1A9pK3NZCCLC0M61gklZZ691Ba7NtR-gM-OzZ8ED0Yce7lerDd8UoE1SQLHB-FIjh2zZbqkaXDAyD9hC2SRGJOW2wpDxDX_8DXYdtzPbvUYQxVkkm_6J6nQdw3ob8rtmLqhkjpOZcEpFRF_9B5dXB6EzwYF2uPyCQA8HEkFIEezcjwWqfQnVIocrhUvsUql3mvLpvzh3jT-zqX-SB2mU</recordid><startdate>20170605</startdate><enddate>20170605</enddate><creator>Winckelmans, Ellen</creator><creator>Vrijens, Karen</creator><creator>Tsamou, Maria</creator><creator>Janssen, Bram G</creator><creator>Saenen, Nelly D</creator><creator>Roels, Harry A</creator><creator>Kleinjans, Jos</creator><creator>Lefebvre, Wouter</creator><creator>Vanpoucke, Charlotte</creator><creator>de Kok, Theo M</creator><creator>Nawrot, Tim S</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170605</creationdate><title>Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort</title><author>Winckelmans, Ellen ; Vrijens, Karen ; Tsamou, Maria ; Janssen, Bram G ; Saenen, Nelly D ; Roels, Harry A ; Kleinjans, Jos ; Lefebvre, Wouter ; Vanpoucke, Charlotte ; de Kok, Theo M ; Nawrot, Tim S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-b60a6e52a6789780eb6ec8087f4fbb6f1ec6ee99dad0145f9faa383d103ae0553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Air Pollutants - analysis</topic><topic>Air Pollutants - toxicity</topic><topic>Air pollution</topic><topic>Airborne particulates</topic><topic>Alcohol</topic><topic>Ambient air pollution</topic><topic>Belgium</topic><topic>Birth weight</topic><topic>Cancer</topic><topic>Childbirth & labor</topic><topic>Cohort Studies</topic><topic>Cord blood</topic><topic>Damage</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA damage</topic><topic>DNA microarrays</topic><topic>Education</topic><topic>Environmental health</topic><topic>Ethnicity</topic><topic>Exposure</topic><topic>Female</topic><topic>Fetal</topic><topic>Fetal Blood - chemistry</topic><topic>Fetuses</topic><topic>Gene expression</topic><topic>Gene set enrichment analysis</topic><topic>Genomes</topic><topic>Girls</topic><topic>Grandparents</topic><topic>Health aspects</topic><topic>Health problems</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Infant, Newborn</topic><topic>Infants (Newborn)</topic><topic>Interpolation</topic><topic>Kinases</topic><topic>Male</topic><topic>Maternal Exposure</topic><topic>Microarray analysis</topic><topic>Mitochondria</topic><topic>Mothers</topic><topic>Neurodevelopment</topic><topic>Outdoor air quality</topic><topic>Parent educational background</topic><topic>Particulate matter</topic><topic>Particulate Matter - analysis</topic><topic>Particulate Matter - toxicity</topic><topic>Pregnancy</topic><topic>RhoA protein</topic><topic>Rope</topic><topic>Sex</topic><topic>Sex Factors</topic><topic>Signatures</topic><topic>Synaptic transmission</topic><topic>Transcriptome - drug effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winckelmans, Ellen</creatorcontrib><creatorcontrib>Vrijens, Karen</creatorcontrib><creatorcontrib>Tsamou, Maria</creatorcontrib><creatorcontrib>Janssen, Bram G</creatorcontrib><creatorcontrib>Saenen, Nelly D</creatorcontrib><creatorcontrib>Roels, Harry A</creatorcontrib><creatorcontrib>Kleinjans, Jos</creatorcontrib><creatorcontrib>Lefebvre, Wouter</creatorcontrib><creatorcontrib>Vanpoucke, Charlotte</creatorcontrib><creatorcontrib>de Kok, Theo M</creatorcontrib><creatorcontrib>Nawrot, Tim S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winckelmans, Ellen</au><au>Vrijens, Karen</au><au>Tsamou, Maria</au><au>Janssen, Bram G</au><au>Saenen, Nelly D</au><au>Roels, Harry A</au><au>Kleinjans, Jos</au><au>Lefebvre, Wouter</au><au>Vanpoucke, Charlotte</au><au>de Kok, Theo M</au><au>Nawrot, Tim S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort</atitle><jtitle>Environmental health</jtitle><addtitle>Environ Health</addtitle><date>2017-06-05</date><risdate>2017</risdate><volume>16</volume><issue>1</issue><spage>52</spage><epage>52</epage><pages>52-52</pages><artnum>52</artnum><issn>1476-069X</issn><eissn>1476-069X</eissn><abstract>Air pollution exposure during pregnancy has been associated with adverse birth outcomes and health problems later in life. We investigated sex-specific transcriptomic responses to gestational long- and short-term exposure to particulate matter with a diameter < 2.5 μm (PM
) in order to elucidate potential underlying mechanisms of action.
Whole genome gene expression was investigated in cord blood of 142 mother-newborn pairs that were enrolled in the ENVIRONAGE birth cohort. Daily PM
exposure levels were calculated for each mother's home address using a spatial-temporal interpolation model in combination with a dispersion model to estimate both long- (annual average before delivery) and short- (last month of pregnancy) term exposure. We explored the association between gene expression levels and PM
exposure, and identified modulated pathways by overrepresentation analysis and gene set enrichment analysis.
Some processes were altered in both sexes for long- (e.g. DNA damage) or short-term exposure (e.g. olfactory signaling). For long-term exposure in boys neurodevelopment and RhoA pathways were modulated, while in girls defensin expression was down-regulated. For short-term exposure we identified pathways related to synaptic transmission and mitochondrial function (boys) and immune response (girls).
This is the first whole genome gene expression study in cord blood to identify sex-specific pathways altered by PM
. The identified transcriptome pathways could provide new molecular insights as to the interaction pattern of early life PM
exposure with the biological development of the fetus.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>28583124</pmid><doi>10.1186/s12940-017-0264-y</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental health, 2017-06, Vol.16 (1), p.52-52, Article 52 |
| issn | 1476-069X 1476-069X |
| language | eng |
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| source | PubMed Central (Open Access); Publicly Available Content Database (Proquest) (PQ_SDU_P3) |
| subjects | Adolescent Adult Air Pollutants - analysis Air Pollutants - toxicity Air pollution Airborne particulates Alcohol Ambient air pollution Belgium Birth weight Cancer Childbirth & labor Cohort Studies Cord blood Damage Deoxyribonucleic acid DNA DNA damage DNA microarrays Education Environmental health Ethnicity Exposure Female Fetal Fetal Blood - chemistry Fetuses Gene expression Gene set enrichment analysis Genomes Girls Grandparents Health aspects Health problems Health risk assessment Humans Immune response Immune system Infant, Newborn Infants (Newborn) Interpolation Kinases Male Maternal Exposure Microarray analysis Mitochondria Mothers Neurodevelopment Outdoor air quality Parent educational background Particulate matter Particulate Matter - analysis Particulate Matter - toxicity Pregnancy RhoA protein Rope Sex Sex Factors Signatures Synaptic transmission Transcriptome - drug effects Young Adult |
| title | Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort |
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