TLR7 Agonist-Loaded Gadolinium Oxide Nanotubes Promote Anti-Tumor Immunity by Activation of Innate and Adaptive Immune Responses

Improving the delivery of biomolecules to DCs and lymph nodes is critical to increasing their anti-tumor efficacy, reducing their off-target side effects, and improving their safety. In this study, Gd O nanotubes with lengths of 70-80 nm, diameters of 20-30 nm, and pore sizes of up to 18 nm were syn...

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Bibliographic Details
Published in:Vaccines (Basel) 2024-04, Vol.12 (4), p.373
Main Authors: Wang, Xiupeng, Hirose, Motohiro, Li, Xia
Format: Article
Language:English
Subjects:
adjuvant
Anticancer properties
Antigens
Biocompatibility
Biomolecules
Cancer
Care and treatment
Dendritic cells
Efficiency
Evaluation
Females
Gadolinium
Gadolinium oxide
Gadolinium oxides
Gd2O3 nanotubes
Health aspects
Immune response
Immunotherapy
Lymph nodes
Lymphatic system
Methods
Nanotechnology
Nanotubes
pH effects
Properties
Radiation
Side effects
Survival
TLR7
TLR7 protein
Toll-like receptors
Tumors
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Summary:Improving the delivery of biomolecules to DCs and lymph nodes is critical to increasing their anti-tumor efficacy, reducing their off-target side effects, and improving their safety. In this study, Gd O nanotubes with lengths of 70-80 nm, diameters of 20-30 nm, and pore sizes of up to 18 nm were synthesized using a facile one-pot solvothermal method. The Gd O nanotubes showed good adsorption capacity of OVA and TLR7a, with a loading efficiency of about 100%. The Gd O nanotubes showed pH-sensitive degradation and biomolecule release properties; the release of gadolinium ions, OVA, and TLR7a was slow at pH 7.4 and fast at pH 5. The Gd O nanotubes showed 2.6-6.0 times higher payload retention around the injection site, 3.1 times higher cellular uptake, 1.7 times higher IL1β secretion, 1.4 times higher TNFα secretion by BMDCs, and markedly enhanced draining lymph node delivery properties. The combination of OVA, TLR7a, and Gd O nanotubes significantly inhibited tumor growth and increased survival rate compared with only OVA-TLR7a, only OVA, and saline. The Gd O nanotubes are biocompatible and can also be used as radiation sensitizers.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines12040373