Ferroptosis Inhibitory Compounds from the Deep-Sea-Derived Fungus Penicillium sp. MCCC 3A00126

Two new xanthones ( and ) were isolated from the deep-sea-derived fungus sp. MCCC 3A00126 along with 34 known compounds ( - ). The structures of the new compounds were established by spectroscopic data. The absolute configuration of was validated by comparison of experimental and calculated ECD spec...

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Published in:Marine drugs 2023-04, Vol.21 (4), p.234
Main Authors: Hao, You-Jia, Zou, Zheng-Biao, Xie, Ming-Min, Zhang, Yong, Xu, Lin, Yu, Hao-Yu, Ma, Hua-Bin, Yang, Xian-Wen
Format: Article
Language:English
Subjects:
Absolute configuration
Acids
Biological activity
Cell Line, Tumor
Cytotoxicity
Deep sea
Deep sea environments
Deep water
Ferroptosis
Fungi
fungus
Leukemia
Metabolites
Microorganisms
Molecular Structure
necroptosis
NMR
Nuclear magnetic resonance
Penicillium
Penicillium - chemistry
Penicillium sp
Spectrum Analysis
Toxicity
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creator Hao, You-Jia
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description Two new xanthones ( and ) were isolated from the deep-sea-derived fungus sp. MCCC 3A00126 along with 34 known compounds ( - ). The structures of the new compounds were established by spectroscopic data. The absolute configuration of was validated by comparison of experimental and calculated ECD spectra. All isolated compounds were evaluated for cytotoxicity and ferroptosis inhibitory activities. Compounds and exerted potent cytotoxicity against CCRF-CEM cells, with IC values of 5.5 and 3.5 μM, respectively, whereas , , , and significantly inhibited RSL3-induced ferroptosis, with EC values of 11.6, 7.2, 11.8, and 2.2 μM, respectively.
doi_str_mv 10.3390/md21040234
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subjects Absolute configuration
Acids
Biological activity
Cell Line, Tumor
Cytotoxicity
Deep sea
Deep sea environments
Deep water
Ferroptosis
Fungi
fungus
Leukemia
Metabolites
Microorganisms
Molecular Structure
necroptosis
NMR
Nuclear magnetic resonance
Penicillium
Penicillium - chemistry
Penicillium sp
Spectrum Analysis
Toxicity
title Ferroptosis Inhibitory Compounds from the Deep-Sea-Derived Fungus Penicillium sp. MCCC 3A00126
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