Genome Analysis of ST1 Bartonella henselae , a Zoonotic Pathogen Causing Endocarditis in an Elderly Patient in China

Infective endocarditis (IE) is a rare disease but with high associated mortality. Currently, the mainstays of diagnosis are still echocardiography and blood cultures. Here, we reported a case of infective endocarditis with negative blood cultures, and blood and aortic valve tissue metagenomic next-g...

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Bibliographic Details
Published in:Infection and drug resistance 2023-01, Vol.16, p.6079-6084
Main Authors: Mu, Xinli, Liang, Jianghong, Qian, Linyan, Zhou, Bing, Zou, Xuehan, Fu, Ying, Zhu, Yongze, Li, Xi, Shi, Jiana
Format: Article
Language:English
Subjects:
bartonella henselae
Case Report
infective endocarditis
metagenomic next-generation sequencing
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Summary:Infective endocarditis (IE) is a rare disease but with high associated mortality. Currently, the mainstays of diagnosis are still echocardiography and blood cultures. Here, we reported a case of infective endocarditis with negative blood cultures, and blood and aortic valve tissue metagenomic next-generation sequencing (mNGS) results suggested . In addition, we obtained the whole genomic sequence of ZJBH strain. To our knowledge, this is the first report of genomic analysis isolated from clinic in China. Furthermore, we described the whole genome sequencing (WGS) data incorporating all from diverse sources worldwide and shed light on underlying risk of transmitted between cats and humans.
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S422345