An in-depth analysis of glycosylated haemoglobin level, body mass index and left ventricular diastolic dysfunction in patients with type 2 diabetes

• Published in: BMC endocrine disorders 2019-08, Vol.19 (1), p.88-88, Article 88
• Main Authors: Zuo, Xin, Liu, Xueting, Chen, Runtian, Ou, Huiting, Lai, Jiabao, Zhang, Youming, Yan, Dewen
• Format: Article
• Language: English
• Subjects: Age; Biomarkers - analysis; Blood Glucose - analysis; Blood pressure; Body Mass Index; Body weight; Case-Control Studies; Cholesterol; Complications and side effects; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diagnosis; Endocrinology; Female; Follow-Up Studies; Glycated Hemoglobin A - analysis; Glycosylated haemoglobin; Glycosylated hemoglobin; Health aspects; Heart; Heart diseases; Hemoglobin; Hemoglobins; Hospitals; Humans; Incidence; Left ventricular diastolic dysfunction; Left ventricular function; Lipoproteins; Male; Metabolism; Middle Aged; Myocardium; Obesity; Obesity - physiopathology; Overweight; Overweight - physiopathology; Prognosis; Risk Factors; Taiwan - epidemiology; Type 2 diabetes; Ventricle; Ventricular Dysfunction, Left - blood; Ventricular Dysfunction, Left - epidemiology; Ventricular Dysfunction, Left - etiology; Weight control
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-019-0419-7

Glycosylated hemoglobin (HbA1c) has a detrimental impact on the myocardium with left ventricular (LV) diastolic dysfunction. Obesity is a risk factor of type 2 diabetes. To understand the relationships between HbA1c, body mass index (BMI) and LV diastolic dysfunction, we performed this interaction analysis in patients with type 2 diabetes. Total 925 type 2 diabetes patients were selected from the patients who were diagnosed and treated at the First Affiliated Hospital of Shenzhen University. Patients' BMI levels were defined as normal (BMI