Neuroprotective Potential of Secondary Metabolites from Melicope lunu-ankenda (Rutaceae)

Plant natural compounds have great potential as alternative medicines for preventing and treating diseases. is one species (family ), which is widely used in traditional medicine, consumed as a salad and a food seasoning. Consumption of different parts of this plant has been reported to exert differ...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-08, Vol.24 (17), p.3109
Main Authors: Abdulwanis Mohamed, Zeinab, Mohamed Eliaser, Enas, Mazzon, Emanuela, Rollin, Patrick, Cheng Lian Ee, Gwendoline, Abdull Razis, Ahmad Faizal
Format: Article
Language:English
Subjects:
Acids
alkaloids
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Butanol
Caffeic acid
Calcium
Calcium (intracellular)
coumarins
Dopamine
Epidemiology
Glycogen
Glycogen synthase kinase 3
Glycogens
Humans
Hydrogen peroxide
Inflammation
Kinases
Medicine, Traditional
Melicope lunu-ankenda
Metabolites
Molecular Structure
neurodegenerative diseases
Neuroprotection
Neuroprotective Agents - chemistry
Neuroprotective Agents - pharmacology
Neurotoxicity
Oxidants
Oxidative stress
Oxidizing agents
Pheochromocytoma cells
Phosphorylation
Phytochemicals - chemistry
Phytochemicals - pharmacology
Polyphenols
Review
Rutaceae - chemistry
Secondary Metabolism
Secondary metabolites
Studies
Tau protein
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Summary:Plant natural compounds have great potential as alternative medicines for preventing and treating diseases. is one species (family ), which is widely used in traditional medicine, consumed as a salad and a food seasoning. Consumption of different parts of this plant has been reported to exert different biological activities such as antioxidant and anti-inflammatory qualities, resulting in a protective effect against several health disorders including neurodegenerative diseases. Various secondary metabolites such as phenolic acid derivatives, flavonoids, coumarins and alkaloids, isolated from the plant, were demonstrated to have neuroprotective activities and also exert many other beneficial biological effects. A number of studies have revealed different neuroprotective mechanisms for these secondary metabolites. This review summarizes the most significant and recent studies for neuroprotective activity of major secondary metabolites in neurodegenerative diseases.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24173109