Palmo-plantar keratoderma with debilitating pruritus

We describe two siblings with diffuse, mutilating palmo-plantar keratoderma suggestive of Olmsted syndrome, with significantly compromised quality of life in the form of inability to walk and grasp objects. This was accompanied by severe pruritus and erythromelalgia-like symptoms. The keratoderma re...

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Bibliographic Details
Published in:Indian journal of paediatric dermatology 2020-07, Vol.21 (3), p.187-190
Main Authors: Kataria, Vandana, Grover, Chander, Pandhi, Deepika
Format: Article
Language:English
Subjects:
acitretin
erythromelalgia
Itching
olmsted syndrome
pseudoainhum
Retinoids
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Summary:We describe two siblings with diffuse, mutilating palmo-plantar keratoderma suggestive of Olmsted syndrome, with significantly compromised quality of life in the form of inability to walk and grasp objects. This was accompanied by severe pruritus and erythromelalgia-like symptoms. The keratoderma responded to acitretin therapy but there was paradoxical worsening of burning and pruritus which were further disabling. The poor response to medical and phototherapy in relieving these symptoms is described.
ISSN:2319-7250
2319-7269
DOI:10.4103/ijpd.IJPD_4_20