Magnesium degradation under physiological conditions – Best practice

This review focusses on the application of physiological conditions for the mechanistic understanding of magnesium degradation. Despite the undisputed relevance of simplified laboratory setups for alloy screening purposes, realistic and predictive in vitro setups are needed. Due to the complexity of...

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Bibliographic Details
Published in:Bioactive materials 2018-06, Vol.3 (2), p.174-185
Main Authors: Gonzalez, Jorge, Hou, Rui Qing, Nidadavolu, Eshwara P.S., Willumeit-Römer, Regine, Feyerabend, Frank
Format: Article
Language:English
Subjects:
Cell culture conditions
Degradation products
Flow conditions
In vitro
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Summary:This review focusses on the application of physiological conditions for the mechanistic understanding of magnesium degradation. Despite the undisputed relevance of simplified laboratory setups for alloy screening purposes, realistic and predictive in vitro setups are needed. Due to the complexity of these systems, the review gives an overview about technical measures, defines some caveats and can be used as a guideline for the establishment of harmonized laboratory approaches. [Display omitted] •Physiological conditions are mandatory for mechanistic understanding of magnesium degradation.•Guidelines and caveats for experimental setups are reviewed.•Media composition is essential for reliable experiments.
ISSN:2452-199X
2452-199X
DOI:10.1016/j.bioactmat.2018.01.003