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Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil
This study describes the characteristics of 31 children with congenital toxoplasmosis children admitted to the University Hospital of Londrina, Southern Brazil, from 2000 to 2010. In total, 23 (85.2%) of the mothers received prenatal care but only four (13.0%) were treated for toxoplasmosis. Birth w...
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| Published in: | The Brazilian journal of infectious diseases 2014-07, Vol.18 (4), p.364-371 |
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| creator | Capobiango, Jaqueline Dario Mitsuka Breganó, Regina Navarro, Italmar Teodorico Rezende Neto, Claudio Pereira Barbante Casella, Antônio Marcelo Ruiz Lopes Mori, Fabiana Maria Pagliari, Sthefany Inoue, Inácio Teruo Reiche, Edna Maria Vissoci |
| description | This study describes the characteristics of 31 children with congenital toxoplasmosis children admitted to the University Hospital of Londrina, Southern Brazil, from 2000 to 2010. In total, 23 (85.2%) of the mothers received prenatal care but only four (13.0%) were treated for toxoplasmosis. Birth weight was |
| doi_str_mv | 10.1016/j.bjid.2013.11.009 |
| format | article |
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In total, 23 (85.2%) of the mothers received prenatal care but only four (13.0%) were treated for toxoplasmosis. Birth weight was <2500g in 37.9% of the infants. During the first month of life, physical examination was normal in 34.5%, and for those with clinical signs and symptoms, the main manifestations were hepatomegaly and/or splenomegaly (62.1%), jaundice (13.8%), and microcephaly (6.9%). During ophthalmic examination, 74.2% of the children exhibited injuries, 58.1% chorioretinitis, 32.3% strabismus, 19.4% microphthalmia, and 16.2% vitreitis. Anti-Toxoplasma gondii IgM antibodies were detected in 48.3% of the children. Imaging brain evaluation was normal in 44.8%; brain calcifications, hydrocephaly, or both conditions were observed in 27.6%, 10.3%, and 17.2%, respectively, of the patients. Patients with cerebrospinal fluid protein≥200mg/dL presented more brain calcifications (p=0.0325). Other sequelae were visual impairment (55.2% of the cases), developmental delay (31.0%), motor deficit (13.8%), convulsion (27.5%), and attention deficit (10.3%). All patients were treated with sulfadiazine, pyrimethamine, and folinic acid, and 55.2% of them exhibited adverse effects. The results demonstrate the significance of the early diagnosis and treatment of toxoplasmosis during pregnancy to reduce congenital toxoplasmosis and its consequences.</description><identifier>ISSN: 1413-8670</identifier><identifier>ISSN: 1678-4391</identifier><identifier>EISSN: 1678-4391</identifier><identifier>DOI: 10.1016/j.bjid.2013.11.009</identifier><identifier>PMID: 24662141</identifier><language>eng</language><publisher>Brazil: Elsevier Editora Ltda</publisher><subject>Adolescent ; Adult ; Antibodies, Protozoan - blood ; Brazil ; Care and treatment ; Causes of ; Child ; Chorioretinitis ; Congenital toxoplasmosis ; Demographic aspects ; Diagnosis ; Female ; Health aspects ; Humans ; Infant, Newborn ; INFECTIOUS DISEASES ; Male ; Neonatal Screening ; Original ; Pregnancy ; Pregnancy Complications, Infectious - therapy ; Retrospective Studies ; Toxoplasma ; Toxoplasma - immunology ; Toxoplasma gondii ; Toxoplasmosis ; Toxoplasmosis, Congenital - complications ; Toxoplasmosis, Congenital - diagnosis ; Young Adult</subject><ispartof>The Brazilian journal of infectious diseases, 2014-07, Vol.18 (4), p.364-371</ispartof><rights>2014 Elsevier Editora Ltda.</rights><rights>Copyright © 2014 Elsevier Editora Ltda. All rights reserved.</rights><rights>COPYRIGHT 2014 Contexto</rights><rights>2014 Elsevier Editora Ltda. All rights reserved. 2014 Elsevier Editora Ltda.</rights><rights>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c728t-ebb0b37e1bd93973ce589bcb0d1d6eed049b84c3419ef8484edf61b2d43be4013</citedby><cites>FETCH-LOGICAL-c728t-ebb0b37e1bd93973ce589bcb0d1d6eed049b84c3419ef8484edf61b2d43be4013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427446/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1413867014000464$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3549,24150,27924,27925,45780,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24662141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Capobiango, Jaqueline Dario</creatorcontrib><creatorcontrib>Mitsuka Breganó, Regina</creatorcontrib><creatorcontrib>Navarro, Italmar Teodorico</creatorcontrib><creatorcontrib>Rezende Neto, Claudio Pereira</creatorcontrib><creatorcontrib>Barbante Casella, Antônio Marcelo</creatorcontrib><creatorcontrib>Ruiz Lopes Mori, Fabiana Maria</creatorcontrib><creatorcontrib>Pagliari, Sthefany</creatorcontrib><creatorcontrib>Inoue, Inácio Teruo</creatorcontrib><creatorcontrib>Reiche, Edna Maria Vissoci</creatorcontrib><title>Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil</title><title>The Brazilian journal of infectious diseases</title><addtitle>Braz J Infect Dis</addtitle><description>This study describes the characteristics of 31 children with congenital toxoplasmosis children admitted to the University Hospital of Londrina, Southern Brazil, from 2000 to 2010. In total, 23 (85.2%) of the mothers received prenatal care but only four (13.0%) were treated for toxoplasmosis. Birth weight was <2500g in 37.9% of the infants. During the first month of life, physical examination was normal in 34.5%, and for those with clinical signs and symptoms, the main manifestations were hepatomegaly and/or splenomegaly (62.1%), jaundice (13.8%), and microcephaly (6.9%). During ophthalmic examination, 74.2% of the children exhibited injuries, 58.1% chorioretinitis, 32.3% strabismus, 19.4% microphthalmia, and 16.2% vitreitis. Anti-Toxoplasma gondii IgM antibodies were detected in 48.3% of the children. Imaging brain evaluation was normal in 44.8%; brain calcifications, hydrocephaly, or both conditions were observed in 27.6%, 10.3%, and 17.2%, respectively, of the patients. Patients with cerebrospinal fluid protein≥200mg/dL presented more brain calcifications (p=0.0325). Other sequelae were visual impairment (55.2% of the cases), developmental delay (31.0%), motor deficit (13.8%), convulsion (27.5%), and attention deficit (10.3%). All patients were treated with sulfadiazine, pyrimethamine, and folinic acid, and 55.2% of them exhibited adverse effects. The results demonstrate the significance of the early diagnosis and treatment of toxoplasmosis during pregnancy to reduce congenital toxoplasmosis and its consequences.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies, Protozoan - blood</subject><subject>Brazil</subject><subject>Care and treatment</subject><subject>Causes of</subject><subject>Child</subject><subject>Chorioretinitis</subject><subject>Congenital toxoplasmosis</subject><subject>Demographic aspects</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>INFECTIOUS DISEASES</subject><subject>Male</subject><subject>Neonatal Screening</subject><subject>Original</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - therapy</subject><subject>Retrospective Studies</subject><subject>Toxoplasma</subject><subject>Toxoplasma - immunology</subject><subject>Toxoplasma gondii</subject><subject>Toxoplasmosis</subject><subject>Toxoplasmosis, Congenital - complications</subject><subject>Toxoplasmosis, Congenital - diagnosis</subject><subject>Young Adult</subject><issn>1413-8670</issn><issn>1678-4391</issn><issn>1678-4391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9Ut2K1TAYLKK46-oLeCEFwStbkyYnbUGE9eDPyoLC6nXIz9dzUtrkkPQs6tv4LL6YX62u2xvpRUoyM5nMN1n2mJKSEipe9KXunS0rQllJaUlIeyc7paJuCs5aehf_OWVFI2pykj1IqSek2hBO7mcnFReiwtPT7MM2-B14N6khn8LXcBhUGkNyKXc-V3mEDiJ4A7kBP0HMQ5d_UlH5nz-e51fhOO0h-vx1VN_d8DC716khwaM_61n25e2bz9v3xeXHdxfb88vC1FUzFaA10awGqm3L2poZ2DStNppYagWAJbzVDTeM0xa6hjccbCeorixnGji-9Sy7WHRtUL08RDeq-E0G5eTvjRB3UsXJmQFkS1CTQd0BcN6CaTRnYComqs4IzTeoVS5ayTgYguzDMXo0L6_m7OScHcbLCcHcCBMcCa8WwuGoR7BzKlENKxfrE-_2cheuZcurmnOBAk8XgZ1Cg853AWFmdMnIc9bgDRu86J-vFQo_C6MzwUPncH9FeHaLsAc1TPsUhuPkgk9rYLUATQwp4XxvvFMi51rJXs61knOtJKUSa4WkJ7dffUP52yMEvFwAgIO_dhDlHCj2xroIZsLJuP_p_wKF89t3</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Capobiango, Jaqueline Dario</creator><creator>Mitsuka Breganó, Regina</creator><creator>Navarro, Italmar Teodorico</creator><creator>Rezende Neto, Claudio Pereira</creator><creator>Barbante Casella, Antônio Marcelo</creator><creator>Ruiz Lopes Mori, Fabiana Maria</creator><creator>Pagliari, Sthefany</creator><creator>Inoue, Inácio Teruo</creator><creator>Reiche, Edna Maria Vissoci</creator><general>Elsevier Editora Ltda</general><general>Contexto</general><general>Elsevier</general><general>Brazilian Society of Infectious Diseases</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>INF</scope><scope>5PM</scope><scope>GPN</scope><scope>DOA</scope></search><sort><creationdate>20140701</creationdate><title>Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil</title><author>Capobiango, Jaqueline Dario ; Mitsuka Breganó, Regina ; Navarro, Italmar Teodorico ; Rezende Neto, Claudio Pereira ; Barbante Casella, Antônio Marcelo ; Ruiz Lopes Mori, Fabiana Maria ; Pagliari, Sthefany ; Inoue, Inácio Teruo ; Reiche, Edna Maria Vissoci</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c728t-ebb0b37e1bd93973ce589bcb0d1d6eed049b84c3419ef8484edf61b2d43be4013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies, Protozoan - blood</topic><topic>Brazil</topic><topic>Care and treatment</topic><topic>Causes of</topic><topic>Child</topic><topic>Chorioretinitis</topic><topic>Congenital toxoplasmosis</topic><topic>Demographic aspects</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>INFECTIOUS DISEASES</topic><topic>Male</topic><topic>Neonatal Screening</topic><topic>Original</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - therapy</topic><topic>Retrospective Studies</topic><topic>Toxoplasma</topic><topic>Toxoplasma - immunology</topic><topic>Toxoplasma gondii</topic><topic>Toxoplasmosis</topic><topic>Toxoplasmosis, Congenital - complications</topic><topic>Toxoplasmosis, Congenital - diagnosis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Capobiango, Jaqueline Dario</creatorcontrib><creatorcontrib>Mitsuka Breganó, Regina</creatorcontrib><creatorcontrib>Navarro, Italmar Teodorico</creatorcontrib><creatorcontrib>Rezende Neto, Claudio Pereira</creatorcontrib><creatorcontrib>Barbante Casella, Antônio Marcelo</creatorcontrib><creatorcontrib>Ruiz Lopes Mori, Fabiana Maria</creatorcontrib><creatorcontrib>Pagliari, Sthefany</creatorcontrib><creatorcontrib>Inoue, Inácio Teruo</creatorcontrib><creatorcontrib>Reiche, Edna Maria Vissoci</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale OneFile: Informe Academico</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>The Brazilian journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Capobiango, Jaqueline Dario</au><au>Mitsuka Breganó, Regina</au><au>Navarro, Italmar Teodorico</au><au>Rezende Neto, Claudio Pereira</au><au>Barbante Casella, Antônio Marcelo</au><au>Ruiz Lopes Mori, Fabiana Maria</au><au>Pagliari, Sthefany</au><au>Inoue, Inácio Teruo</au><au>Reiche, Edna Maria Vissoci</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil</atitle><jtitle>The Brazilian journal of infectious diseases</jtitle><addtitle>Braz J Infect Dis</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>18</volume><issue>4</issue><spage>364</spage><epage>371</epage><pages>364-371</pages><issn>1413-8670</issn><issn>1678-4391</issn><eissn>1678-4391</eissn><abstract>This study describes the characteristics of 31 children with congenital toxoplasmosis children admitted to the University Hospital of Londrina, Southern Brazil, from 2000 to 2010. In total, 23 (85.2%) of the mothers received prenatal care but only four (13.0%) were treated for toxoplasmosis. Birth weight was <2500g in 37.9% of the infants. During the first month of life, physical examination was normal in 34.5%, and for those with clinical signs and symptoms, the main manifestations were hepatomegaly and/or splenomegaly (62.1%), jaundice (13.8%), and microcephaly (6.9%). During ophthalmic examination, 74.2% of the children exhibited injuries, 58.1% chorioretinitis, 32.3% strabismus, 19.4% microphthalmia, and 16.2% vitreitis. Anti-Toxoplasma gondii IgM antibodies were detected in 48.3% of the children. Imaging brain evaluation was normal in 44.8%; brain calcifications, hydrocephaly, or both conditions were observed in 27.6%, 10.3%, and 17.2%, respectively, of the patients. Patients with cerebrospinal fluid protein≥200mg/dL presented more brain calcifications (p=0.0325). Other sequelae were visual impairment (55.2% of the cases), developmental delay (31.0%), motor deficit (13.8%), convulsion (27.5%), and attention deficit (10.3%). All patients were treated with sulfadiazine, pyrimethamine, and folinic acid, and 55.2% of them exhibited adverse effects. The results demonstrate the significance of the early diagnosis and treatment of toxoplasmosis during pregnancy to reduce congenital toxoplasmosis and its consequences.</abstract><cop>Brazil</cop><pub>Elsevier Editora Ltda</pub><pmid>24662141</pmid><doi>10.1016/j.bjid.2013.11.009</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | PubMed (Medline); SciELO Brazil; ScienceDirect® |
| subjects | Adolescent Adult Antibodies, Protozoan - blood Brazil Care and treatment Causes of Child Chorioretinitis Congenital toxoplasmosis Demographic aspects Diagnosis Female Health aspects Humans Infant, Newborn INFECTIOUS DISEASES Male Neonatal Screening Original Pregnancy Pregnancy Complications, Infectious - therapy Retrospective Studies Toxoplasma Toxoplasma - immunology Toxoplasma gondii Toxoplasmosis Toxoplasmosis, Congenital - complications Toxoplasmosis, Congenital - diagnosis Young Adult |
| title | Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil |
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