Predictive factors for perinatal bacterial transmission from colonized mothers to delivered very-low-birth-weight infants: a retrospective cohort study

This study investigated the predictive factors for perinatal bacterial transmission in very-low-birth-weight infants (VLBWIs) born to mothers with a history of intrapartum colonization. We retrospectively reviewed the medical records of 173 VLBWIs, wherein pathogens were confirmed in maternal cultur...

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Bibliographic Details
Published in:Scientific reports 2024-07, Vol.14 (1), p.16835-10, Article 16835
Main Authors: Hwang, Jieun, Kim, Sumin, Kim, Hanna, Kim, Chan, Kim, Seung Hyun, Yang, Misun, Ahn, So Yoon, Sung, Se In, Chang, Yun Sil
Format: Article
Language:English
Subjects:
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692/499
Adult
Birth
Birth weight
Blood
C-reactive protein
Chorioamnionitis
Colonization
E coli
Escherichia coli - isolation & purification
Female
Hemorrhage
Humanities and Social Sciences
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Infants
Infectious Disease Transmission, Vertical
Leukocytosis
Low birth weight
Male
Medical records
Mothers
multidisciplinary
Neonates
Pathogens
Pregnancy
Pregnancy Complications, Infectious - microbiology
Retrospective Studies
Risk Factors
Science
Science (multidisciplinary)
Citations: Items that this one cites
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Summary:This study investigated the predictive factors for perinatal bacterial transmission in very-low-birth-weight infants (VLBWIs) born to mothers with a history of intrapartum colonization. We retrospectively reviewed the medical records of 173 VLBWIs, wherein pathogens were confirmed in maternal cultures obtained from the blood, urine, and vagina during the intrapartum period from 2013 to 2020. Newborns were categorized based on microbiological tests, including gastric aspirates, endotracheal aspirates, blood, and skin/nasal swab cultures collected immediately after birth. Infants whose cultures matched their maternal pathogens were categorized into the “transmission group” (n = 45), while those who tested negative were assigned to the “control group” (n = 128). The predominant maternal-colonizing pathogen observed was Escherichia coli (30.6%), which also emerged as the primary colonizing pathogen in neonates (35.6%). Transmission group had higher incidences of maternal leukocytosis, chorioamnionitis, and cervical cerclage. Regarding neonatal characteristics, the transmission group demonstrated lower initial base excesses (− 6.3 ± 3.9 vs. − 9.2 ± 4.9, P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-67674-7