Physiotherapeutic Protocol and ZnO Nanoparticles: A Combined Novel Treatment Program against Bacterial Pyomyositis

or pyomyositis is a muscle inflammation resulting from a bacterial infection of skeletal muscle (commonly caused by ) that usually leads to hematogenous muscle seeding. The present study was designed to estimate the role of ZnO-NPs and a physiotherapeutic program in the management of induced atrophy...

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Bibliographic Details
Published in:Biology (Basel, Switzerland) Switzerland), 2022-09, Vol.11 (10), p.1393
Main Authors: El-Shaer, Hesham, Elwakil, Bassma H, Bakr, Basant A, Eldrieny, Ahmed M, El-Khatib, Mostafa, Chong, Khim Phin, Abo Gazia, Amr A
Format: Article
Language:English
Subjects:
Animals
Antibacterial activity
Antimicrobial agents
Atrophy
Bacterial infections
Cytotoxicity
Enzymatic activity
Enzymes
Hemostasis
infected rat model
Lasers
Minimum inhibitory concentration
Myoblasts
Myositis
Nanoparticles
Physical therapy
physiotherapeutic program
Proteolysis
Proteolytic bacteria
Proteolytic enzymes
Pyomyositis
Quality of life
Skeletal muscle
Staphylococcus aureus
Strains (organisms)
Tissue engineering
zinc oxide nanoparticles
Zinc oxides
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Summary:or pyomyositis is a muscle inflammation resulting from a bacterial infection of skeletal muscle (commonly caused by ) that usually leads to hematogenous muscle seeding. The present study was designed to estimate the role of ZnO-NPs and a physiotherapeutic program in the management of induced atrophy in rats through histological, biochemical, and radiological examinations at different time intervals. At the beginning, several bacterial strains were evaluated through a proteolytic enzyme activity assay and the highest activity was recorded with the strain. ZnO-NPs were synthesized with the arc discharge method with an average size of 19.4 nm. The antibacterial activity of ZnO-NPs was investigated and it was revealed that the prepared ZnO-NPs showed a minimum inhibitory concentration of 8 µg/mL against the tested bacterium. The cytotoxicity of the prepared ZnO-NPs was tested in C2C12 myoblast cells, and it was elaborated that CC50 was 344.16 µg/mL. pyomyositis was induced with a potent strain ( ); then, a physiotherapeutic program combined with the prepared ZnO-NPs treatment protocol was applied and evaluated. The combined program claimed antibacterial properties, preventing muscle atrophy, and resulted in the most comparable value of muscle mass.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology11101393