Advances of adipose-derived mesenchymal stem cells-based biomaterial scaffolds for oral and maxillofacial tissue engineering

The management of oral and maxillofacial tissue defects caused by tumors, trauma, and congenital or acquired deformities has been a major challenge for surgeons over the last few decades. Autologous tissue transplantation, the gold standard of tissue reconstruction, is a valid method for repairing t...

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Bibliographic Details
Published in:Bioactive materials 2021-08, Vol.6 (8), p.2467-2478
Main Authors: Liu, Tong, Xu, Jia, Pan, Xun, Ding, Zhangfan, Xie, Hao, Wang, Xiaoyi, Xie, Huixu
Format: Article
Language:English
Subjects:
Adipose-derived mesenchymal stem cell
Biomaterial scaffold
Oral and maxillofacial
Tissue engineering
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Summary:The management of oral and maxillofacial tissue defects caused by tumors, trauma, and congenital or acquired deformities has been a major challenge for surgeons over the last few decades. Autologous tissue transplantation, the gold standard of tissue reconstruction, is a valid method for repairing the oral and maxillofacial functions and aesthetics. However, several limitations hinder its clinical applications including complications of donor sites, limited tissue volume, and uncertain long-term outcomes. Adipose-derived mesenchymal stem cells (ADMSCs) widely exist in adipose tissue and can be easily obtained through liposuction. Like the bone marrow-derived mesenchymal stem cells (BMSCs), ADMSCs also have the multi-pluripotent potencies to differentiate into osteoblasts, chondrocytes, neurons, and myocytes. Therefore, the multilineage capacity of ADMSCs makes them valuable for cell-based medical therapies. In recent years, researchers have developed many candidates of ADMSCs-based biomaterial scaffolds to cater for the needs of oral and maxillofacial tissue engineering due to their superior performance. This review presents the advances and applications of ADMSCs-based biomaterial scaffolds, and explores their tissue engineering prospects in oral and maxillofacial reconstructions. [Display omitted] •ADMSCs are more available than BMSCs and their multipotential differentiation ability is excellent.•ADMSCs and biomaterial scaffolds could complement each other.•ADMSCs-based biomaterial scaffolds have broad prospects in tissue engineering.
ISSN:2452-199X
2452-199X
DOI:10.1016/j.bioactmat.2021.01.015