Cervical Carcinoma: Oncobiology and Biomarkers

Cervical cancer is one of the most common types of carcinomas causing morbidity and mortality in women in all countries of the world. At the moment, the oncology, oncobiology, and oncomorphology of cervical cancer are characterized by the accumulation of new information; various molecular biological...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-11, Vol.22 (22), p.12571
Main Authors: Volkova, Larisa V, Pashov, Alexander I, Omelchuk, Nadezhda N
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers, Tumor - genetics
Cancer therapies
Carcinogenesis
Carcinogenesis - genetics
Carcinogens
Carcinoma
carcinoma of the cervix
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - therapy
Cervical cancer
cervical carcinogenesis
Cervical carcinoma
Cervix
Cervix Uteri - pathology
Epigenetics
Female
Genomes
Human papillomavirus
Humans
immunohistochemistry
Infections
Morbidity
Mortality
Oncology
Proteins
Review
Tumors
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - therapy
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Summary:Cervical cancer is one of the most common types of carcinomas causing morbidity and mortality in women in all countries of the world. At the moment, the oncology, oncobiology, and oncomorphology of cervical cancer are characterized by the accumulation of new information; various molecular biological, genetic, and immunohistochemical methods of investigation of the mechanisms of cervical carcinogenesis are tested and applied; targeted antitumour drugs and diagnostic, prognostic, and predictive biomarkers are being searched for. Many issues of the etiopathogenesis of cervical cancer have not been sufficiently studied, and the role of many biomarkers characterizing various stages of cervical carcinogenesis remains unclear. Therefore, the target of this review is to systematize and understand several problems in the pathogenesis of cervical cancer and to evaluate the significance and role of biomarkers in cervical carcinogenesis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms222212571