Incidence and Prognostic Significance of PD-L1 Expression in High-Grade Salivary Gland Carcinoma

PD-L1 is one of the predictors of immunotherapy efficacy. Our goal was to analyze its expression and prognostic significance in high-grade salivary gland carcinoma (SGC). PD-L1 expression was evaluated using paraffin-embedded specimens from patients with surgically treated high-grade SGC, and it was...

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Bibliographic Details
Published in:Frontiers in oncology 2021-08, Vol.11, p.701181-701181
Main Authors: Fang, Qigen, Wu, Yao, Du, Wei, Zhang, Xu, Chen, Defeng
Format: Article
Language:English
Subjects:
high-grade salivary gland carcinoma
immunotherapy
Oncology
PD-L1
salivary gland carcinoma
survival
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Summary:PD-L1 is one of the predictors of immunotherapy efficacy. Our goal was to analyze its expression and prognostic significance in high-grade salivary gland carcinoma (SGC). PD-L1 expression was evaluated using paraffin-embedded specimens from patients with surgically treated high-grade SGC, and it was scored by the tumor proportion score (TPS), combined positive score (CPS), and immune cell (IC) score. Associations between clinicopathological variables, disease-free survival (DFS), overall survival (OS) and PD-L1 expression were assessed. TPS≥1% occurred in 47 patients with an incidence of 43.1%, and it was significantly related to an advanced tumor stage. In patients with TPS
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.701181