Prognostic significance of mutated genes in megakaryocytic disorders

Megakaryopoiesis is a process during which platelets that play a major role in hemostasis are produced due to differentiation and maturation of megakaryocytic precursors. Several genes, including oncogenes and tumor suppressor genes, play a role in the regulation of this process. This study was cond...

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Bibliographic Details
Published in:Oncology reviews 2019-07, Vol.13 (2), p.408-408
Main Authors: Asnafi, Ali Amin, Mohammadi, Mohammad Bagher, Rezaeeyan, Hadi, Davari, Nader, Saki, Najmaldin
Format: Article
Language:English
Subjects:
Amino acids
Apoptosis
Blood diseases
Cell cycle
Cell growth
Cytokines
Genes
Kinases
Leukemia
Megakaryocytic disorders
Mutation
Proteins
Review
Thrombocytopenia
Transcription factors
Citations: Items that this one cites
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Summary:Megakaryopoiesis is a process during which platelets that play a major role in hemostasis are produced due to differentiation and maturation of megakaryocytic precursors. Several genes, including oncogenes and tumor suppressor genes, play a role in the regulation of this process. This study was conducted to investigate the oncogenes and tumor suppressor genes as well as their mutations during the megakaryopoiesis process, which can lead to megakaryocytic disorders. Relevant literature was identified by a PubMed search (1998-2019) of English language papers using the terms ' , and According to investigations, several mutations occur in the genes implicated in megakaryopoiesis, which abnormally induce or inhibit megakaryocyte production, differentiation, and maturation, leading to platelet disorders. GATA-1 is one of the important genes in megakaryopoiesis and its mutations can be considered among the factors involved in the incidence of these disorders. Considering the essential role of these genes (such as GATA- 1) in megakaryopoiesis and the involvement of their mutations in platelet disorders, study and examination of these changes can be a positive step in the diagnosis and prognosis of these diseases.
ISSN:1970-5565
1970-5557
1970-5565
1970-5557
DOI:10.4081/oncol.2019.408