Multifunctional sponge scaffold loaded with concentrated growth factors for promoting wound healing

• Published in: iScience 2023-01, Vol.26 (1), p.105835, Article 105835
• Main Authors: Chen, Lianglong, Huang, Chaoyang, Zhong, Yu, Chen, Yujia, Zhang, Huihui, Zheng, Zijun, Jiang, Ziwei, Wei, Xuerong, Peng, Yujie, Huang, Lei, Niu, Libin, Gao, Yanbin, Ma, Jun, Yang, Lei
• Format: Article
• Language: English
• Subjects: Biological sciences; Biomaterials; Biomedical engineering; Materials science
• ISSN: 2589-0042; 2589-0042
• DOI: 10.1016/j.isci.2022.105835

Although both are applied in regenerative medicine, acellular dermal matrix (ADM) and concentrated growth factor (CGF) have their respective shortcoming: The functioning of CGF is often hindered by sudden release effects, among other problems, and ADM can only be used in outer dressing for wound healing. In this study, a compound network with physical-chemical double cross-linking was constructed using chemical cross-linking and the intertwining of ADM and chitosan chains under freezing conditions; equipped with good biocompatibility and cell/tissue affinity, the heparin-modified composite scaffold was able to significantly promote cell adhesion and proliferation to achieve adequate fixation and slow down the release of CGF; polydopamine nanoparticles having excellent near-infrared light photothermal conversion ability could significantly promote the survival of rat autologous skin grafts. In a word, this multifunctional composite scaffold is a promising new type of implant biomaterial capable of delivering CGF to promote the healing of full-thickness skin defects. [Display omitted] •We constructed a multifunctional composite scaffold that can load more CGF•The scaffold has good biocompatibility and photothermal conversion efficiency•The scaffold promotes faster wound healing, better vascularization, and less scar formation