Genus Smenospongia: Untapped Treasure of Biometabolites—Biosynthesis, Synthesis, and Bioactivities

Marine sponges continue to attract remarkable attention as one of the richest pools of bioactive metabolites in the marine environment. The genus Smenospongia (order Dictyoceratida, family Thorectidae) sponges can produce diverse classes of metabolites with unique and unusual chemical skeletons, inc...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-09, Vol.27 (18), p.5969
Main Authors: Ibrahim, Sabrin R. M., Fadil, Sana A., Fadil, Haifa A., Hareeri, Rawan H., Abdallah, Hossam M., Mohamed, Gamal A.
Format: Article
Language:English
Subjects:
Alkenes
Alzheimer's disease
Antidepressants
Bioactive compounds
bioactivities
Biological activity
Biosynthesis
Chemists
Cytotoxicity
indole alkaloids
Kinases
Malaria
Marine environment
marine sponges
Metabolites
Polyketides
Review
Serotonin
sesquiterpenoids
Smenospongia
Sponges
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Summary:Marine sponges continue to attract remarkable attention as one of the richest pools of bioactive metabolites in the marine environment. The genus Smenospongia (order Dictyoceratida, family Thorectidae) sponges can produce diverse classes of metabolites with unique and unusual chemical skeletons, including terpenoids (sesqui-, di-, and sesterterpenoids), indole alkaloids, aplysinopsins, bisspiroimidazolidinones, chromenes, γ-pyrones, phenyl alkenes, naphthoquinones, and polyketides that possessed diversified bioactivities. This review provided an overview of the reported metabolites from Smenospongia sponges, including their biosynthesis, synthesis, and bioactivities in the period from 1980 to June 2022. The structural characteristics and diverse bioactivities of these metabolites could attract a great deal of attention from natural-product chemists and pharmaceuticals seeking to develop these metabolites into medicine for the treatment and prevention of certain health concerns.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27185969