Porphyrin Macrocycles: General Properties and Theranostic Potential

Despite specialists' efforts to find the best solutions for cancer diagnosis and therapy, this pathology remains the biggest health threat in the world. Global statistics concerning deaths associated with cancer are alarming; therefore, it is necessary to intensify interdisciplinary research in...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2023-01, Vol.28 (3), p.1149
Main Authors: Boscencu, Rica, Radulea, Natalia, Manda, Gina, Machado, Isabel Ferreira, Socoteanu, Radu Petre, Lupuliasa, Dumitru, Burloiu, Andreea Mihaela, Mihai, Dragos Paul, Ferreira, Luis Filipe Vieira
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
Diagnosis
Health aspects
Health risks
Humans
Interdisciplinary aspects
Interdisciplinary research
Interdisciplinary studies
Neoplasms - diagnosis
Neoplasms - drug therapy
Nitrogen
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - therapeutic use
porphyrin macrocycles
Porphyrins
Porphyrins - chemistry
Precision Medicine
Review
theranostic agents
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Summary:Despite specialists' efforts to find the best solutions for cancer diagnosis and therapy, this pathology remains the biggest health threat in the world. Global statistics concerning deaths associated with cancer are alarming; therefore, it is necessary to intensify interdisciplinary research in order to identify efficient strategies for cancer diagnosis and therapy, by using new molecules with optimal therapeutic potential and minimal adverse effects. This review focuses on studies of porphyrin macrocycles with regard to their structural and spectral profiles relevant to their applicability in efficient cancer diagnosis and therapy. Furthermore, we present a critical overview of the main commercial formulations, followed by short descriptions of some strategies approached in the development of third-generation photosensitizers.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28031149