Subsiding of Periodontitis in the Permanent Dentition in Individuals with Papillon-Lefèvre Syndrome through Specific Periodontal Treatment: A Systematic Review

Papillon-Lefèvre syndrome (PLS) is a rare hereditary disease characterized by palmoplantar hyperkeratosis (PPK) and periodontitis in the primary and permanent dentition, usually resulting in edentulism in youth. Subsiding of PLS-associated periodontitis through specific therapy has occasionally been...

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Bibliographic Details
Published in:Healthcare (Basel) 2022-12, Vol.10 (12), p.2505
Main Authors: Schnabl, Dagmar, Thumm, Felix Maximilian, Kapferer-Seebacher, Ines, Eickholz, Peter
Format: Article
Language:English
Subjects:
Antibiotics
Bias
Biofilms
Care and treatment
Clinical trials
Cohort analysis
Connective tissue
Control
Cross-sectional studies
Development and progression
Diagnosis
Genetic aspects
Granulocytes
Gum disease
Haim–Munk Syndrome
Identification and classification
Laboratories
Microbial mats
Mutation
Papillon-Lefevre disease
Papillon–Lefèvre syndrome
periodontal treatment
Periodontitis
Systematic review
Teeth
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Summary:Papillon-Lefèvre syndrome (PLS) is a rare hereditary disease characterized by palmoplantar hyperkeratosis (PPK) and periodontitis in the primary and permanent dentition, usually resulting in edentulism in youth. Subsiding of PLS-associated periodontitis through specific therapy has occasionally been reported. We aimed to systematically assess periodontal treatment strategies that may decelerate disease progression. A systematic literature search was conducted at PubMed/LIVIVO/Ovid (Prospero registration number CRD42021223253). Clinical studies describing periodontal treatment success-defined as loss of ≤four permanent teeth because of periodontitis and the arrest of periodontitis or probing depths ≤ 5 mm-in individuals with PLS followed up for ≥24 months. Out of the 444 primarily identified studies, 12 studies reporting nine individuals were included. The timely extraction of affected or, alternatively, all primary teeth, compliance with oral hygiene instructions, supra- and subgingival debridement within frequent supportive periodontal care intervals, and-in eight patients-adjunctive systemic antibiotic therapy (mostly amoxicillin/metronidazole) effected a halt in disease progression. The suppression of below the detection limit was correlated with the subsiding of periodontitis. Successful controlling of PLS-associated periodontitis may be achieved if high effort and patient compliance are provided.
ISSN:2227-9032
2227-9032
DOI:10.3390/healthcare10122505