Incidence, risk factors and prognosis of acute kidney injury in patients treated with immune checkpoint inhibitors: a retrospective study

Immune checkpoint inhibitors (ICIs) change the prognosis of many cancer patients. With the increasing use of ICIs, immune-related adverse events are occurring, including acute kidney injury (AKI). This study aimed to assess the incidence of AKI during ICI treatment and its risk factors and impact on...

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Bibliographic Details
Published in:Scientific reports 2022-11, Vol.12 (1), p.18752-11, Article 18752
Main Authors: Ji, Ming-Su, Wu, Rilige, Feng, Zhe, Wang, Yuan-Da, Wang, Yong, Zhang, Li, Sun, Xue-Feng, Chen, Xiang-Mei, He, Kun-Lun, Cai, Guang-Yan
Format: Article
Language:English
Subjects:
692/4022
692/4028
Acute Kidney Injury - chemically induced
Acute Kidney Injury - epidemiology
Anemia
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Chemotherapy
Death
Diuretics
Diuretics - adverse effects
Humanities and Social Sciences
Humans
Immune checkpoint inhibitors
Immune Checkpoint Inhibitors - adverse effects
Incidence
Kidneys
Medical prognosis
Mortality
multidisciplinary
Nonsteroidal anti-inflammatory drugs
Patients
Prognosis
Proton pump inhibitors
Regression analysis
Renal function
Retrospective Studies
Risk Factors
Science
Science (multidisciplinary)
Survival analysis
Tumors
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Summary:Immune checkpoint inhibitors (ICIs) change the prognosis of many cancer patients. With the increasing use of ICIs, immune-related adverse events are occurring, including acute kidney injury (AKI). This study aimed to assess the incidence of AKI during ICI treatment and its risk factors and impact on mortality. Patients treated with ICIs at the First Medical Center of the Chinese PLA General Hospital from January 1, 2014, to December 30, 2019, were consecutively enrolled, and risk factors affecting AKI development in patients treated with ICIs were analyzed using univariate and multivariate logistic regression. Medical record surveys and telephone inquiry were used for follow-up, and Kaplan–Meier survival analysis and Cox regression were used to analyze independent risk factors for death. Among 1615 patients, 114 (7.1%) had AKI. Multivariate logistic regression analysis showed that anemia, Alb 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-21912-y