Cytotoxicity of NeoMTA Plus, ProRoot MTA and Biodentine on human dental pulp stem cells

Dental pulp stem cells (DPSCs) play a crucial role in the tissue healing process through odontoblast like cell differentiation. The aim of this study was to evaluate the biocompatibility and compare the potential invitro cytotoxic effects of NeoMTA Plus, ProRootMTA and Biodentine on human dental pul...

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Bibliographic Details
Published in:Journal of dental sciences 2021-07, Vol.16 (3), p.971-979
Main Authors: Birant, Sinem, Gokalp, Muazzez, Duran, Yazgul, Koruyucu, Mine, Akkoc, Tunc, Seymen, Figen
Format: Article
Language:English
Subjects:
Cytotoxicity
Dental pulp stem cells
Mineral trioxide aggregate
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Summary:Dental pulp stem cells (DPSCs) play a crucial role in the tissue healing process through odontoblast like cell differentiation. The aim of this study was to evaluate the biocompatibility and compare the potential invitro cytotoxic effects of NeoMTA Plus, ProRootMTA and Biodentine on human dental pulp stem cells (hDPSCs). To assess the effects of NeoMTA Plus, ProRoot MTA and Biodentine extracts at 1st, 3rd and 7th d on hDPCs, cell populations was determined by flow cytometry using an Annexin V detection kit. The data were analyzed statistically using the Kruskal–Wallis test. A p  0.05). All materials extracts are not cytotoxic and do not induce apoptosis in the hDPSCs. These results suggest that all the tested materials can lead to positive outcomes when used as reparative biomaterials.
ISSN:1991-7902
2213-8862
DOI:10.1016/j.jds.2020.10.009