Genes Related to Fat Metabolism in Pigs and Intramuscular Fat Content of Pork: A Focus on Nutrigenetics and Nutrigenomics

• Published in: Animals (Basel) 2022-01, Vol.12 (2), p.150
• Main Authors: Malgwi, Isaac Hyeladi, Halas, Veronika, Grünvald, Petra, Schiavon, Stefano, Jócsák, Ildikó
• Format: Article
• Language: English
• Subjects: Adipocytes; Animal diseases; Deposition; Diet; Dietary intake; Disease resistance; DNA methylation; Epigenetics; Fat metabolism; Fatty acids; Flavor; Flavors; Gene expression; Gene mapping; Genes; Genomes; Genomics; Hogs; Influence; intramuscular fat; Lipids; Meat quality; Metabolic pathways; Metabolism; Metabolites; Molecular modelling; Muscles; Mutation; Nucleotides; Nutrient requirements; Nutrients; nutrigenetics; Nutrigenomics; Nutrition research; Pork; Proteins; Proteomics; Quantitative trait loci; Review; Sensory evaluation; Sensory properties; Single-nucleotide polymorphism; Swine; Swine production
• ISSN: 2076-2615; 2076-2615
• DOI: 10.3390/ani12020150

Fat metabolism and intramuscular fat (IMF) are qualitative traits in pigs whose development are influenced by several genes and metabolic pathways. Nutrigenetics and nutrigenomics offer prospects in estimating nutrients required by a pig. Application of these emerging fields in nutritional science provides an opportunity for matching nutrients based on the genetic make-up of the pig for trait improvements. Today, integration of high throughput "omics" technologies into nutritional genomic research has revealed many quantitative trait loci (QTLs) and single nucleotide polymorphisms (SNPs) for the mutation(s) of key genes directly or indirectly involved in fat metabolism and IMF deposition in pigs. Nutrient-gene interaction and the underlying molecular mechanisms involved in fatty acid synthesis and marbling in pigs is difficult to unravel. While existing knowledge on QTLs and SNPs of genes related to fat metabolism and IMF development is yet to be harmonized, the scientific explanations behind the nature of the existing correlation between the nutrients, the genes and the environment remain unclear, being inconclusive or lacking precision. This paper aimed to: (1) discuss nutrigenetics, nutrigenomics and epigenetic mechanisms controlling fat metabolism and IMF accretion in pigs; (2) highlight the potentials of these concepts in pig nutritional programming and research.