Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment

Alternative splicing (AS) is an important event that contributes to posttranscriptional gene regulation. This process leads to several mature transcript variants with diverse physiological functions. Indeed, disruption of various aspects of this multistep process, such as cis- or trans- factor alter...

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Bibliographic Details
Published in:Cell death & disease 2021-07, Vol.12 (8), p.752-752, Article 752
Main Authors: Chen, Yanyan, Huang, Mengxi, Liu, Xiaolong, Huang, Yadi, Liu, Chao, Zhu, Jialong, Fu, Gongbo, Lei, Zengjie, Chu, Xiaoyuan
Format: Article
Language:English
Subjects:
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Alternative splicing
Alternative Splicing - genetics
Animals
Antibodies
Apoptosis - genetics
Biochemistry
Biomedical and Life Sciences
Cancer
Cell Biology
Cell Culture
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - blood supply
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - genetics
Colorectal Neoplasms - therapy
Gene regulation
Humans
Immunology
Life Sciences
Post-transcription
Protein Processing, Post-Translational
Review
Review Article
RNA, Messenger - genetics
RNA, Messenger - metabolism
Spliceosomes - metabolism
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Summary:Alternative splicing (AS) is an important event that contributes to posttranscriptional gene regulation. This process leads to several mature transcript variants with diverse physiological functions. Indeed, disruption of various aspects of this multistep process, such as cis- or trans- factor alteration, promotes the progression of colorectal cancer. Therefore, targeting some specific processes of AS may be an effective therapeutic strategy for treating cancer. Here, we provide an overview of the AS events related to colorectal cancer based on research done in the past 5 years. We focus on the mechanisms and functions of variant products of AS that are relevant to malignant hallmarks, with an emphasis on variants with clinical significance. In addition, novel strategies for exploiting the therapeutic value of AS events are discussed.
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-021-04031-w