Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment

Alternative splicing (AS) is an important event that contributes to posttranscriptional gene regulation. This process leads to several mature transcript variants with diverse physiological functions. Indeed, disruption of various aspects of this multistep process, such as cis- or trans- factor alter...

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Published in:Cell death & disease 2021-07, Vol.12 (8), p.752-752, Article 752
Main Authors: Chen, Yanyan, Huang, Mengxi, Liu, Xiaolong, Huang, Yadi, Liu, Chao, Zhu, Jialong, Fu, Gongbo, Lei, Zengjie, Chu, Xiaoyuan
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Language:English
Subjects:
38
38/91
631/337
631/67/2324
631/80
Alternative splicing
Alternative Splicing - genetics
Animals
Antibodies
Apoptosis - genetics
Biochemistry
Biomedical and Life Sciences
Cancer
Cell Biology
Cell Culture
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - blood supply
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - genetics
Colorectal Neoplasms - therapy
Gene regulation
Humans
Immunology
Life Sciences
Post-transcription
Protein Processing, Post-Translational
Review
Review Article
RNA, Messenger - genetics
RNA, Messenger - metabolism
Spliceosomes - metabolism
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creator Chen, Yanyan
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description Alternative splicing (AS) is an important event that contributes to posttranscriptional gene regulation. This process leads to several mature transcript variants with diverse physiological functions. Indeed, disruption of various aspects of this multistep process, such as cis- or trans- factor alteration, promotes the progression of colorectal cancer. Therefore, targeting some specific processes of AS may be an effective therapeutic strategy for treating cancer. Here, we provide an overview of the AS events related to colorectal cancer based on research done in the past 5 years. We focus on the mechanisms and functions of variant products of AS that are relevant to malignant hallmarks, with an emphasis on variants with clinical significance. In addition, novel strategies for exploiting the therapeutic value of AS events are discussed.
doi_str_mv 10.1038/s41419-021-04031-w
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subjects 38
38/91
631/337
631/67/2324
631/80
Alternative splicing
Alternative Splicing - genetics
Animals
Antibodies
Apoptosis - genetics
Biochemistry
Biomedical and Life Sciences
Cancer
Cell Biology
Cell Culture
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - blood supply
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - genetics
Colorectal Neoplasms - therapy
Gene regulation
Humans
Immunology
Life Sciences
Post-transcription
Protein Processing, Post-Translational
Review
Review Article
RNA, Messenger - genetics
RNA, Messenger - metabolism
Spliceosomes - metabolism
title Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment
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