Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy

Diosmin is widely used in the treatment of chronic venous diseases and hemorrhoids. Based on Raman and infrared reflection spectra of powdered tablets in the mid- and near-infrared regions and results of reference high-performance liquid chromatographic analysis, partial least squares models that en...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-11, Vol.27 (23), p.8276
Main Authors: Pielorz, Sonia, Węglińska, Magdalena, Mazurek, Sylwester, Szostak, Roman
Format: Article
Language:English
Subjects:
Analysis
Calibration
Care and treatment
Chromatography
Citrus fruits
Diosmin
Efficiency
Errors
Flavonoids
Government agencies
Hemorrhoids
infrared
Infrared analysis
Infrared reflection
Infrared spectra
Infrared spectroscopy
Least-Squares Analysis
NIR
Pharmaceutical industry
pharmaceutical preparations
Polyvinyl alcohol
Quality assessment
Quantitative analysis
Raman
Raman spectroscopy
Sensors
Sodium
Software
Solvents
Spectrum analysis
Spectrum Analysis, Raman - methods
Tablets
Tablets - chemistry
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Summary:Diosmin is widely used in the treatment of chronic venous diseases and hemorrhoids. Based on Raman and infrared reflection spectra of powdered tablets in the mid- and near-infrared regions and results of reference high-performance liquid chromatographic analysis, partial least squares models that enable fast and reliable quantification of the studied active ingredient in tablets, without the need for extraction, were elaborated. Eight commercial preparations containing diosmin in the 66-92% ( / ) range were analyzed. In order to assess and compare the quality of the developed chemometric models, the relative standard errors of prediction for calibration and validation sets were calculated. We found these errors to be in the 1.0-2.4% range for the three spectroscopic techniques used. Diosmin content in the analyzed preparations was obtained with recoveries in the 99.5-100.5% range.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27238276