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Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy
Diosmin is widely used in the treatment of chronic venous diseases and hemorrhoids. Based on Raman and infrared reflection spectra of powdered tablets in the mid- and near-infrared regions and results of reference high-performance liquid chromatographic analysis, partial least squares models that en...
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| Published in: | Molecules (Basel, Switzerland) Switzerland), 2022-11, Vol.27 (23), p.8276 |
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| cited_by | cdi_FETCH-LOGICAL-c560t-3365730aeb2093a520c390a91185670ad510853efc0502b3548f404569bf9abe3 |
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| cites | cdi_FETCH-LOGICAL-c560t-3365730aeb2093a520c390a91185670ad510853efc0502b3548f404569bf9abe3 |
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| container_issue | 23 |
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| container_title | Molecules (Basel, Switzerland) |
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| creator | Pielorz, Sonia Węglińska, Magdalena Mazurek, Sylwester Szostak, Roman |
| description | Diosmin is widely used in the treatment of chronic venous diseases and hemorrhoids. Based on Raman and infrared reflection spectra of powdered tablets in the mid- and near-infrared regions and results of reference high-performance liquid chromatographic analysis, partial least squares models that enable fast and reliable quantification of the studied active ingredient in tablets, without the need for extraction, were elaborated. Eight commercial preparations containing diosmin in the 66-92% (
/
) range were analyzed. In order to assess and compare the quality of the developed chemometric models, the relative standard errors of prediction for calibration and validation sets were calculated. We found these errors to be in the 1.0-2.4% range for the three spectroscopic techniques used. Diosmin content in the analyzed preparations was obtained with recoveries in the 99.5-100.5% range. |
| doi_str_mv | 10.3390/molecules27238276 |
| format | article |
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/
) range were analyzed. In order to assess and compare the quality of the developed chemometric models, the relative standard errors of prediction for calibration and validation sets were calculated. We found these errors to be in the 1.0-2.4% range for the three spectroscopic techniques used. Diosmin content in the analyzed preparations was obtained with recoveries in the 99.5-100.5% range.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules27238276</identifier><identifier>PMID: 36500369</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Analysis ; Calibration ; Care and treatment ; Chromatography ; Citrus fruits ; Diosmin ; Efficiency ; Errors ; Flavonoids ; Government agencies ; Hemorrhoids ; infrared ; Infrared analysis ; Infrared reflection ; Infrared spectra ; Infrared spectroscopy ; Least-Squares Analysis ; NIR ; Pharmaceutical industry ; pharmaceutical preparations ; Polyvinyl alcohol ; Quality assessment ; Quantitative analysis ; Raman ; Raman spectroscopy ; Sensors ; Sodium ; Software ; Solvents ; Spectrum analysis ; Spectrum Analysis, Raman - methods ; Tablets ; Tablets - chemistry</subject><ispartof>Molecules (Basel, Switzerland), 2022-11, Vol.27 (23), p.8276</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-3365730aeb2093a520c390a91185670ad510853efc0502b3548f404569bf9abe3</citedby><cites>FETCH-LOGICAL-c560t-3365730aeb2093a520c390a91185670ad510853efc0502b3548f404569bf9abe3</cites><orcidid>0000-0002-8096-5229 ; 0000-0001-5544-3448 ; 0000-0002-5436-7284</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2748556709/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2748556709?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25733,27903,27904,36991,36992,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36500369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pielorz, Sonia</creatorcontrib><creatorcontrib>Węglińska, Magdalena</creatorcontrib><creatorcontrib>Mazurek, Sylwester</creatorcontrib><creatorcontrib>Szostak, Roman</creatorcontrib><title>Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>Diosmin is widely used in the treatment of chronic venous diseases and hemorrhoids. Based on Raman and infrared reflection spectra of powdered tablets in the mid- and near-infrared regions and results of reference high-performance liquid chromatographic analysis, partial least squares models that enable fast and reliable quantification of the studied active ingredient in tablets, without the need for extraction, were elaborated. Eight commercial preparations containing diosmin in the 66-92% (
/
) range were analyzed. In order to assess and compare the quality of the developed chemometric models, the relative standard errors of prediction for calibration and validation sets were calculated. We found these errors to be in the 1.0-2.4% range for the three spectroscopic techniques used. Diosmin content in the analyzed preparations was obtained with recoveries in the 99.5-100.5% range.</description><subject>Analysis</subject><subject>Calibration</subject><subject>Care and treatment</subject><subject>Chromatography</subject><subject>Citrus fruits</subject><subject>Diosmin</subject><subject>Efficiency</subject><subject>Errors</subject><subject>Flavonoids</subject><subject>Government agencies</subject><subject>Hemorrhoids</subject><subject>infrared</subject><subject>Infrared analysis</subject><subject>Infrared reflection</subject><subject>Infrared spectra</subject><subject>Infrared spectroscopy</subject><subject>Least-Squares Analysis</subject><subject>NIR</subject><subject>Pharmaceutical industry</subject><subject>pharmaceutical preparations</subject><subject>Polyvinyl alcohol</subject><subject>Quality assessment</subject><subject>Quantitative analysis</subject><subject>Raman</subject><subject>Raman spectroscopy</subject><subject>Sensors</subject><subject>Sodium</subject><subject>Software</subject><subject>Solvents</subject><subject>Spectrum analysis</subject><subject>Spectrum Analysis, Raman - methods</subject><subject>Tablets</subject><subject>Tablets - chemistry</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUttu1DAQjRCIXuADeEGReOFli69J_IJUtVxWqoSg5dma2OPFq8Re7KTS_j3ebildQLZkz_ic4zn2VNUrSs44V-TdGAc084CZtYx3rG2eVMdUMLLgRKinj_ZH1UnOa0IYFVQ-r454IwnhjTqurr_OECY_weRvsb7ECdPoQ4liqKOrL33MJa7LvIF-wCnX_bZeBpcgoa0h2PobjBDq6w2aKcVs4mb7onrmYMj48n49rb5__HBz8Xlx9eXT8uL8amFkQ6YFL1W0nAD2jCgOkhFTTIGitJNNS8BKSjrJ0RkiCeu5FJ0TRMhG9U5Bj_y0Wu51bYS13iQ_QtrqCF7fJWJaaUiTNwNqRaxywirRgBDOSNVIa0lnlXXC0aYtWu_3Wpu5H9EaDFOC4UD08CT4H3oVb7VqS01MFYG39wIp_pwxT3r02eAwQMA4Z81ayTntWtUV6Ju_oOs4p1CeqqBEJ3fu1R_UCooBH1ws95qdqD5vRXEglOIFdfYfVBkWR29iQOdL_oBA9wRTfisndA8eKdG7rtL_dFXhvH78OA-M323EfwHMwch8</recordid><startdate>20221127</startdate><enddate>20221127</enddate><creator>Pielorz, Sonia</creator><creator>Węglińska, Magdalena</creator><creator>Mazurek, Sylwester</creator><creator>Szostak, Roman</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8096-5229</orcidid><orcidid>https://orcid.org/0000-0001-5544-3448</orcidid><orcidid>https://orcid.org/0000-0002-5436-7284</orcidid></search><sort><creationdate>20221127</creationdate><title>Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy</title><author>Pielorz, Sonia ; Węglińska, Magdalena ; Mazurek, Sylwester ; Szostak, Roman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-3365730aeb2093a520c390a91185670ad510853efc0502b3548f404569bf9abe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Calibration</topic><topic>Care and treatment</topic><topic>Chromatography</topic><topic>Citrus fruits</topic><topic>Diosmin</topic><topic>Efficiency</topic><topic>Errors</topic><topic>Flavonoids</topic><topic>Government agencies</topic><topic>Hemorrhoids</topic><topic>infrared</topic><topic>Infrared analysis</topic><topic>Infrared reflection</topic><topic>Infrared spectra</topic><topic>Infrared spectroscopy</topic><topic>Least-Squares Analysis</topic><topic>NIR</topic><topic>Pharmaceutical industry</topic><topic>pharmaceutical preparations</topic><topic>Polyvinyl alcohol</topic><topic>Quality assessment</topic><topic>Quantitative analysis</topic><topic>Raman</topic><topic>Raman spectroscopy</topic><topic>Sensors</topic><topic>Sodium</topic><topic>Software</topic><topic>Solvents</topic><topic>Spectrum analysis</topic><topic>Spectrum Analysis, Raman - methods</topic><topic>Tablets</topic><topic>Tablets - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pielorz, Sonia</creatorcontrib><creatorcontrib>Węglińska, Magdalena</creatorcontrib><creatorcontrib>Mazurek, Sylwester</creatorcontrib><creatorcontrib>Szostak, Roman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pielorz, Sonia</au><au>Węglińska, Magdalena</au><au>Mazurek, Sylwester</au><au>Szostak, Roman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2022-11-27</date><risdate>2022</risdate><volume>27</volume><issue>23</issue><spage>8276</spage><pages>8276-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>Diosmin is widely used in the treatment of chronic venous diseases and hemorrhoids. Based on Raman and infrared reflection spectra of powdered tablets in the mid- and near-infrared regions and results of reference high-performance liquid chromatographic analysis, partial least squares models that enable fast and reliable quantification of the studied active ingredient in tablets, without the need for extraction, were elaborated. Eight commercial preparations containing diosmin in the 66-92% (
/
) range were analyzed. In order to assess and compare the quality of the developed chemometric models, the relative standard errors of prediction for calibration and validation sets were calculated. We found these errors to be in the 1.0-2.4% range for the three spectroscopic techniques used. Diosmin content in the analyzed preparations was obtained with recoveries in the 99.5-100.5% range.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36500369</pmid><doi>10.3390/molecules27238276</doi><orcidid>https://orcid.org/0000-0002-8096-5229</orcidid><orcidid>https://orcid.org/0000-0001-5544-3448</orcidid><orcidid>https://orcid.org/0000-0002-5436-7284</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Calibration Care and treatment Chromatography Citrus fruits Diosmin Efficiency Errors Flavonoids Government agencies Hemorrhoids infrared Infrared analysis Infrared reflection Infrared spectra Infrared spectroscopy Least-Squares Analysis NIR Pharmaceutical industry pharmaceutical preparations Polyvinyl alcohol Quality assessment Quantitative analysis Raman Raman spectroscopy Sensors Sodium Software Solvents Spectrum analysis Spectrum Analysis, Raman - methods Tablets Tablets - chemistry |
| title | Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy |
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