N- Propargylamines: versatile building blocks in the construction of thiazole cores

Thiazoles and their hydrogenated analogues are not only key structural units in a wide variety of natural products but they also constitute important building blocks in medicinal chemistry. Therefore, the synthesis of these compounds using new protocols is always interesting. It is well known that -...

Full description

Saved in:
Bibliographic Details
Published in:Beilstein journal of organic chemistry 2017-03, Vol.13 (1), p.625-638
Main Authors: Arshadi, S, Vessally, E, Edjlali, L, Hosseinzadeh-Khanmiri, R, Ghorbani-Kalhor, E
Format: Article
Language:English
Subjects:
5-exo-dig cyclization
6-endo-dig cyclization
Carbon
Chemistry
Construction
Hydrogenation
Kinases
N-heterocycles
N-propargylamines
Natural products
Review
Thiazoles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thiazoles and their hydrogenated analogues are not only key structural units in a wide variety of natural products but they also constitute important building blocks in medicinal chemistry. Therefore, the synthesis of these compounds using new protocols is always interesting. It is well known that -propargylamines can undergo a number of cyclization reactions to produce various nitrogen-containing heterocycles. In this review, we highlight the most important developments on the synthesis of thiazole and its derivatives starting from -propargylamines. This review will be helpful in the development of improved methods for the synthesis of natural and biologically important compounds.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.13.61