Agarwood Alcohol Extract Ameliorates Isoproterenol-Induced Myocardial Ischemia by Inhibiting Oxidation and Apoptosis

Agarwood is a traditional medicine used for treating some diseases, including painful and ischemic diseases. This study was carried out to investigate the potential cardioprotective effect of the whole-tree agarwood-inducing technique-produced agarwood alcohol extract (WTAAE) on isoproterenol- (ISO-...

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Bibliographic Details
Published in:Cardiology research and practice 2020, Vol.2020 (2020), p.1-10
Main Authors: Guo, Peng, Yu, Zhangxin, Liu, Yangyang, Peng, Deqian, Wang, Canhong, Wei, Jianhe
Format: Article
Language:English
Subjects:
Alcohol
Angina pectoris
Apoptosis
Aspartate
Cardiac glycosides
Cardiotonic agents
Chinese medicine
Comparative analysis
Electrocardiography
Enzymes
Ethylenediaminetetraacetic acid
Herbal medicine
Ischemia
Laboratory animals
Medical research
Medicine, Experimental
Myocardial ischemia
Pathogenesis
Peroxides
RNA
Software
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Summary:Agarwood is a traditional medicine used for treating some diseases, including painful and ischemic diseases. This study was carried out to investigate the potential cardioprotective effect of the whole-tree agarwood-inducing technique-produced agarwood alcohol extract (WTAAE) on isoproterenol- (ISO-) induced myocardial ischemia (MI) in rats and explore the underlying molecular mechanisms. Compared to the MI group, WTAAE pretreatment significantly improved ST wave abnormal-elevation, mitigated myocardial histological damage; decreased creatinine kinase (CK), lactate dehydrogenase (LDH), alanine transaminase (ALT), and aspartate transaminase (AST) levels; reduced hydrogen peroxide (H2O2) and lipid peroxide (LPO) production; and increased total antioxidant capacity (T-AOC) and catalase (CAT) activities. Moreover, agarwood alcohol extracts (AAEs) markedly enhanced the mRNA levels of Nrf2-ARE pathway, and Bcl-2 reduced the apoptotic Bax family mRNA expressions. In addition, the effect of WTAAE was greater than that of wild agarwood alcohol extract (WAAE) and burning-chisel-drilling agarwood alcohol extract (FBAAE). All of these data indicate that WTAAE exerted the protective effects of MI, and its mechanism was associated with upregulating Nrf2-ARE and suppressing Bcl-2 pathways.
ISSN:2090-8016
2090-0597
2090-0597
DOI:10.1155/2020/3640815