Sickle Cell Disease and Pregnancy

Sickle cell disease (SCD) is the most common inherited hemoglobinopathy and is associated with increased risk of complications and early mortality. Nowadays, with improved health care facilities, antibiotic prophylaxis, vaccination, and availability of drugs like hydroxyurea, the life expectancy of...

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Bibliographic Details
Published in:Mediterranean journal of hematology and infectious diseases 2019, Vol.11 (1), p.e2019040-e2019040
Main Authors: Jain, Dipty, Atmapoojya, Prachi, Colah, Roshan, Lodha, Pooja
Format: Article
Language:English
Subjects:
Anemia
Developing Countries
Pregnancy
Review
Sickle Cell Disease
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Summary:Sickle cell disease (SCD) is the most common inherited hemoglobinopathy and is associated with increased risk of complications and early mortality. Nowadays, with improved health care facilities, antibiotic prophylaxis, vaccination, and availability of drugs like hydroxyurea, the life expectancy of SCD patients has improved. More women are reaching reproductive age group and are expressing their desire to reproduce. Though SCD adversely affects pregnancy, leading to increased incidence of maternal and perinatal complications like pre-eclampsia, preterm labor, IUGR, abortions etc., adequate care throughout pregnancy ensures a better outcome. Also, recent advancements in the fields of prenatal diagnosis and preimplantation genetic diagnosis, help couples suffering from SCD to have a healthy baby. This paper focuses on the effects of SCD on pregnancy outcomes and effective management of complications during pregnancy, also comparing maternal and perinatal outcomes in studies conducted in different countries. The second part of the paper summarizes pregnancy management in SCD for better maternal and fetal outcomes.
ISSN:2035-3006
2035-3006
DOI:10.4084/MJHID.2019.040