A ubiquitous endocrine disruptor tributyltin induces muscle wasting and retards muscle regeneration

Background Organotin pollutant tributyltin (TBT) is an environmental endocrine disrupting chemical and is a known obesogen and diabetogen. TBT can be detected in human following consumption of contaminated seafood or water. The decrease in muscle strength and quality has been shown to be associated...

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Published in:Journal of cachexia, sarcopenia and muscle sarcopenia and muscle, 2023-02, Vol.14 (1), p.167-181
Main Authors: Chiu, Hsien‐Chun, Yang, Rong‐Sen, Weng, Te‐I, Chiu, Chen‐Yuan, Lan, Kuo‐Cheng, Liu, Shing‐Hwa
Format: Article
Language:English
Subjects:
Aged
Animals
Antibodies
Atrophy
Birth weight
Cachexia - pathology
Diabetes
Diabetes Mellitus, Type 2
Digital cameras
Endocrine disruptors
Endocrine Disruptors - metabolism
Endocrine Disruptors - pharmacology
Environmental pollutants
Experiments
Frequency distribution
Glucose
Glycerol
Humans
Insulin
Metabolic disorders
Mice
Muscle regeneration
Muscle strength
Muscle wasting
Muscle, Skeletal - pathology
Muscular Atrophy - pathology
Muscular Diseases - metabolism
Myogenesis
Myostatin - metabolism
Original
Regeneration - physiology
Software
Tributyltin
Variance analysis
Wood preservatives
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Summary:Background Organotin pollutant tributyltin (TBT) is an environmental endocrine disrupting chemical and is a known obesogen and diabetogen. TBT can be detected in human following consumption of contaminated seafood or water. The decrease in muscle strength and quality has been shown to be associated with type 2 diabetes in older adults. However, the adverse effects of TBT on the muscle mass and function still remain unclear. Here, we investigated the effects and molecule mechanisms of low‐dose TBT on skeletal muscle regeneration and atrophy/wasting using the cultured skeletal muscle cell and adult mouse models. Methods The mouse myoblasts (C2C12) and differentiated myotubes were used to assess the in vitro effects of low‐dose tributyltin (0.01–0.5 μM). The in vivo effects of TBT at the doses of 5 and 25 μg/kg/day (n = 6/group), which were five times lower than the established no observed adverse effect level (NOAEL) and equal to NOAEL, respectively, by oral administration for 4 weeks on muscle wasting and muscle regeneration were evaluated in a mouse model with or without glycerol‐induced muscle injury/regeneration. Results TBT reduced myogenic differentiation in myoblasts (myotube with 6–10 nuclei: 53.9 and 35.8% control for 0.05 and 0.1 μM, respectively, n = 4, P 
ISSN:2190-5991
2190-6009
DOI:10.1002/jcsm.13119