Dual Stimuli-Triggered Nanogels in Response to Temperature and pH Changes for Controlled Drug Release

Poly- N -isopropyl acrylamide (PNIPAM) nanogels have been modified with different acrylic acid (AAc) contents for the efficient control of lower critical solution temperature (LCST). In this study, PNIPAM-co-AAc nanogels nanogels showed two volume phase transitions in comparison with PNIPAM. The tra...

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Bibliographic Details
Published in:Nanoscale research letters 2019-03, Vol.14 (1), p.77-9, Article 77
Main Authors: Kim, Yun Kyoung, Kim, Eun-Joong, Lim, Jae Hyun, Cho, Heui Kyoung, Hong, Woo Jin, Jeon, Hyang Hwa, Chung, Bong Geun
Format: Article
Language:English
Subjects:
Acrylamide
Acrylic acid
Body temperature
Cell proliferation
Chemistry and Materials Science
Colorimetry
Controlled drug release
Drug delivery
Drug delivery systems
Fluorescence
Intestine
Lapachone
LCST
Low level
Materials Science
Molecular Medicine
Nano Express
Nanochemistry
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
pH effects
Phase transitions
PNIPAM
Temperature
Temperature effects
Transition temperature
Transition temperatures
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Summary:Poly- N -isopropyl acrylamide (PNIPAM) nanogels have been modified with different acrylic acid (AAc) contents for the efficient control of lower critical solution temperature (LCST). In this study, PNIPAM-co-AAc nanogels nanogels showed two volume phase transitions in comparison with PNIPAM. The transition temperature of PNIPAM nanogels was increased with AAc contents. The controlled drug release performance of PNIPAM-co-AAc nanogels loaded with β-lapachone was attributed to the AAc content ratio and was efficiently triggered in response to temperature and pH. Moreover, a colorimetric cell proliferation assay and direct fluorescence-based live/dead staining were used to confirm the concurrence on drug release profiles. Finally, PNIPAM-co-AAc20 showed a relatively low level of drug release in the range of acidic to neutral pH at body temperature, while maximizing drug release at basic pH. Therefore, we demonstrated that the PNIPAM-based nanogel with the temperature- and pH-responsive features could be a promising nanocarrier for potential intestine-specific drug delivery.
ISSN:1931-7573
1556-276X
DOI:10.1186/s11671-019-2909-y