Cryogels: Advancing Biomaterials for Transformative Biomedical Applications

Cryogels, composed of synthetic and natural materials, have emerged as versatile biomaterials with applications in tissue engineering, controlled drug delivery, regenerative medicine, and therapeutics. However, optimizing cryogel properties, such as mechanical strength and release profiles, remains...

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Bibliographic Details
Published in:Pharmaceutics 2023-06, Vol.15 (7), p.1836
Main Authors: Omidian, Hossein, Dey Chowdhury, Sumana, Babanejad, Niloofar
Format: Article
Language:English
Subjects:
Behavior
Biocompatibility
Biological products
biomaterials
biomedical applications
Biomedical materials
Cancer therapies
cryogels
drug delivery
Drug delivery systems
Drugs
Hydrogels
Nanocomposites
Nanoparticles
Physical properties
Polymers
Proteins
Review
Solvents
Tissue engineering
Vehicles
Wound healing
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Summary:Cryogels, composed of synthetic and natural materials, have emerged as versatile biomaterials with applications in tissue engineering, controlled drug delivery, regenerative medicine, and therapeutics. However, optimizing cryogel properties, such as mechanical strength and release profiles, remains challenging. To advance the field, researchers are exploring advanced manufacturing techniques, biomimetic design, and addressing long-term stability. Combination therapies and drug delivery systems using cryogels show promise. In vivo evaluation and clinical trials are crucial for safety and efficacy. Overcoming practical challenges, including scalability, structural integrity, mass transfer constraints, biocompatibility, seamless integration, and cost-effectiveness, is essential. By addressing these challenges, cryogels can transform biomedical applications with innovative biomaterials.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15071836