Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer

• Published in: Scientific reports 2017-07, Vol.7 (1), p.5708-14, Article 5708
• Main Authors: Imamura, Taisuke, Komatsu, Shuhei, Ichikawa, Daisuke, Miyamae, Mahito, Okajima, Wataru, Ohashi, Takuma, Kiuchi, Jun, Nishibeppu, Keiji, Konishi, Hirotaka, Shiozaki, Atsushi, Morimura, Ryo, Ikoma, Hisashi, Ochiai, Toshiya, Okamoto, Kazuma, Taniguchi, Hiroki, Otsuji, Eigo
• Format: Article
• Language: English
• Subjects: 38; 38/61; 631/67/1504/1713; 631/67/1857; Aged; Animals; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Cell Line, Tumor; Cell Proliferation; Female; Gene regulation; Humanities and Social Sciences; Humans; Liver; Liver Neoplasms - secondary; Male; Metastases; Mice, SCID; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; miRNA; multidisciplinary; Neoplasm Staging; Neoplasm Transplantation; Pancreatic cancer; Pancreatic Neoplasms - blood; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Plasma levels; Prognosis; Science; Science (multidisciplinary); Transcription; Tumor suppressor genes
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-06137-8

This study explored decreased tumor suppressor microRNA (miRNA) plasma levels in pancreatic cancer (PCa) patients to clarify their potential as novel biomarkers and therapeutic targets. We used the microRNA array-based approach to select candidates by comparing plasma levels between PCa patients and healthy volunteers. Six down-regulated miRNAs (miR-107, miR-126, miR-451, miR-145, miR-491-5p, and miR-146b-5p) were selected. Small- and large-scale analyses using samples from 100 PCa patients and 80 healthy volunteers revealed that miR-107 was the most down-regulated miRNA in PCa patients compared with healthy volunteers ( P