Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study

Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association with microstructural brain alterations is unclear. To address this, we examined the association of coffee consumption with brain MRI parameters representing vascular brain damage, neurodegenera...

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Bibliographic Details
Published in:Nutrients 2023-01, Vol.15 (3), p.674
Main Authors: Mayer, Carola, Nägele, Felix L, Petersen, Marvin, Schell, Maximilian, Aarabi, Ghazal, Beikler, Thomas, Borof, Katrin, Frey, Benedikt M, Nikorowitsch, Julius, Senftinger, Juliana, Walther, Carolin, Wenzel, Jan-Per, Zyriax, Birgit-Christiane, Cheng, Bastian, Thomalla, Götz
Format: Article
Language:English
Subjects:
Alcohol
Alzheimer's disease
Body mass index
Brain
Brain - diagnostic imaging
Brain damage
Brain injury
Cerebral cortex
cerebral small vessel disease
Coffee
coffee consumption
Consumption
cortical atrophy
Cups
Diabetes
Diet
diffusion-weighted magnetic resonance imaging
Health aspects
Humans
Hypertension
Magnetic Resonance Imaging
microstructural integrity
Microstructure
Neurodegeneration
neurodegenerative diseases
Neuroimaging
Physiological aspects
Regression analysis
Risk factors
Substantia alba
Thickness
White Matter - diagnostic imaging
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Summary:Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association with microstructural brain alterations is unclear. To address this, we examined the association of coffee consumption with brain MRI parameters representing vascular brain damage, neurodegeneration, and microstructural integrity in 2316 participants in the population-based Hamburg City Health Study. Cortical thickness and white matter hyperintensity (WMH) load were measured on FLAIR and T1-weighted images. Microstructural white matter integrity was quantified as peak width of skeletonized mean diffusivity (PSMD) on diffusion-weighted MRI. Daily coffee consumption was assessed in five groups (6 cups). In multiple linear regressions, we examined the association between brain MRI parameters and coffee consumption (reference group
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15030674