A 10-Year Follow-Up of Excessive Daytime Sleepiness in Parkinson’s Disease

Introduction. The aim of this prospective study was to investigate excessive daytime sleepiness (EDS) over time and in relation to other PD symptoms among people with Parkinson’s disease (PD). Methods. Thirty participants younger than 65 years with PD were randomly selected. At inclusion, mean (SD)...

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Published in:Parkinson's disease 2019, Vol.2019 (2019), p.1-7
Main Authors: Sorjonen, Kimmo, Pålhagen, Sven, Broman, Jan-Erik, Hagell, Peter, Höglund, Arja, Fredrikson, Sten
Format: Article
Language:English
Subjects:
Antidepressants
Anxiety
Cognitive ability
Consent
Daytime
Dementia
Diabetes
Dopamine
Fatigue
Gait
Health Sciences
Hälsovetenskap
Medical and Health Sciences
Medical research
Medicin och hälsovetenskap
Medicine, Experimental
Mental depression
Movement disorders
Neurodegenerative diseases
Parkinson's disease
Posture
Sleep
Sleep and wakefulness
Sleep deprivation
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container_end_page 7
container_issue 2019
container_start_page 1
container_title Parkinson's disease
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creator Sorjonen, Kimmo
Pålhagen, Sven
Broman, Jan-Erik
Hagell, Peter
Höglund, Arja
Fredrikson, Sten
description Introduction. The aim of this prospective study was to investigate excessive daytime sleepiness (EDS) over time and in relation to other PD symptoms among people with Parkinson’s disease (PD). Methods. Thirty participants younger than 65 years with PD were randomly selected. At inclusion, mean (SD) disease duration was 6.2 (4.8) years and median (min-max) severity of PD was classified as stage II (stages I–III) according to Hoehn and Yahr. Participants were followed annually for 10 years with clinical assessments of their PD status, medications, comorbidities, and a standardized interview about their sleep habits and occurrence of daytime sleepiness. EDS was assessed by the self-reported Epworth Sleepiness Scale (ESS). Seventeen participants completed the 10-year longitudinal follow-up. Results. Fifteen of 30 persons were classified to suffer from EDS (ESS > 10) at baseline. At the group level, EDS remained stable over 10 years and did not deteriorate in parallel with worsening of motor symptoms. Furthermore, EDS was associated with sleep quality, fatigue, anxiety, depression, and axial/postural/gait impairments. Conclusions. EDS did not worsen over 10 years, although other PD aspects did. EDS in PD seems to be a complex nonmotor symptom that is unrelated to deterioration of motor symptoms in PD.
doi_str_mv 10.1155/2019/5708515
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The aim of this prospective study was to investigate excessive daytime sleepiness (EDS) over time and in relation to other PD symptoms among people with Parkinson’s disease (PD). Methods. Thirty participants younger than 65 years with PD were randomly selected. At inclusion, mean (SD) disease duration was 6.2 (4.8) years and median (min-max) severity of PD was classified as stage II (stages I–III) according to Hoehn and Yahr. Participants were followed annually for 10 years with clinical assessments of their PD status, medications, comorbidities, and a standardized interview about their sleep habits and occurrence of daytime sleepiness. EDS was assessed by the self-reported Epworth Sleepiness Scale (ESS). Seventeen participants completed the 10-year longitudinal follow-up. Results. Fifteen of 30 persons were classified to suffer from EDS (ESS &gt; 10) at baseline. At the group level, EDS remained stable over 10 years and did not deteriorate in parallel with worsening of motor symptoms. Furthermore, EDS was associated with sleep quality, fatigue, anxiety, depression, and axial/postural/gait impairments. Conclusions. EDS did not worsen over 10 years, although other PD aspects did. 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The aim of this prospective study was to investigate excessive daytime sleepiness (EDS) over time and in relation to other PD symptoms among people with Parkinson’s disease (PD). Methods. Thirty participants younger than 65 years with PD were randomly selected. At inclusion, mean (SD) disease duration was 6.2 (4.8) years and median (min-max) severity of PD was classified as stage II (stages I–III) according to Hoehn and Yahr. Participants were followed annually for 10 years with clinical assessments of their PD status, medications, comorbidities, and a standardized interview about their sleep habits and occurrence of daytime sleepiness. EDS was assessed by the self-reported Epworth Sleepiness Scale (ESS). Seventeen participants completed the 10-year longitudinal follow-up. Results. Fifteen of 30 persons were classified to suffer from EDS (ESS &gt; 10) at baseline. 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The aim of this prospective study was to investigate excessive daytime sleepiness (EDS) over time and in relation to other PD symptoms among people with Parkinson’s disease (PD). Methods. Thirty participants younger than 65 years with PD were randomly selected. At inclusion, mean (SD) disease duration was 6.2 (4.8) years and median (min-max) severity of PD was classified as stage II (stages I–III) according to Hoehn and Yahr. Participants were followed annually for 10 years with clinical assessments of their PD status, medications, comorbidities, and a standardized interview about their sleep habits and occurrence of daytime sleepiness. EDS was assessed by the self-reported Epworth Sleepiness Scale (ESS). Seventeen participants completed the 10-year longitudinal follow-up. Results. Fifteen of 30 persons were classified to suffer from EDS (ESS &gt; 10) at baseline. 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source Wiley Online Library Open Access; Publicly Available Content Database; PubMed Central
subjects Antidepressants
Anxiety
Cognitive ability
Consent
Daytime
Dementia
Diabetes
Dopamine
Fatigue
Gait
Health Sciences
Hälsovetenskap
Medical and Health Sciences
Medical research
Medicin och hälsovetenskap
Medicine, Experimental
Mental depression
Movement disorders
Neurodegenerative diseases
Parkinson's disease
Posture
Sleep
Sleep and wakefulness
Sleep deprivation
title A 10-Year Follow-Up of Excessive Daytime Sleepiness in Parkinson’s Disease
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