Impact of Molecular Weight Variations in Dendrobium officinale Polysaccharides on Antioxidant Activity and Anti-Obesity in Caenorhabditis elegans

This research investigates the impact of polysaccharides (DOP) with different molecular weights on antioxidant effects, lifespan enhancement, and obesity reduction, utilizing both in vitro analyses and the ( ) model. Through a series of experiments-ranging from the extraction and modification of pol...

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Bibliographic Details
Published in:Foods 2024-03, Vol.13 (7), p.1040
Main Authors: Pang, Xiao, Wang, Heqin, Guan, Chunbo, Chen, Qiufeng, Cui, Xinwen, Zhang, Xiuqing
Format: Article
Language:English
Subjects:
Acids
antioxidant
Antioxidants
Biological activity
C. elegans
Caenorhabditis elegans
Dendrobium officinale
Dietary supplements
Fat metabolism
Functional foods & nutraceuticals
Gastrointestinal surgery
Gel chromatography
Hydrogen peroxide
Investigations
Life span
Lipid metabolism
Lipids
Metabolism
Molecular weight
Obesity
Polysaccharides
Reagents
Saccharides
structural modification
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Summary:This research investigates the impact of polysaccharides (DOP) with different molecular weights on antioxidant effects, lifespan enhancement, and obesity reduction, utilizing both in vitro analyses and the ( ) model. Through a series of experiments-ranging from the extraction and modification of polysaccharides, Gel Permeation Chromatography (GPC), and analysis of composition to the evaluation of antioxidant capabilities, this study thoroughly examines DOP and its derivatives (DOP5, DOP15, DOP25) produced via H O -Fe degradation. The results reveal a direct relationship between the molecular weight of polysaccharides and their bioactivity. Notably, DOP5, with its intermediate molecular weight, demonstrated superior antioxidant properties, significantly extended the lifespan, and improved the health of Furthermore, DOP15 appeared to regulate lipid metabolism by affecting crucial lipid metabolism genes, including fat-4, fat-5, fat-6, sbp-1, and acs-2. These findings highlight the potential application of DOP derivatives as natural antioxidants and agents against obesity, contributing to the development of functional foods and dietary supplements.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods13071040