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Impact of Molecular Weight Variations in Dendrobium officinale Polysaccharides on Antioxidant Activity and Anti-Obesity in Caenorhabditis elegans
This research investigates the impact of polysaccharides (DOP) with different molecular weights on antioxidant effects, lifespan enhancement, and obesity reduction, utilizing both in vitro analyses and the ( ) model. Through a series of experiments-ranging from the extraction and modification of pol...
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| Published in: | Foods 2024-03, Vol.13 (7), p.1040 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c426t-683a207ce6b54d3ecf772bbd4d91e193e96b52acd642718196d7d55e9f0c245b3 |
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| container_issue | 7 |
| container_start_page | 1040 |
| container_title | Foods |
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| creator | Pang, Xiao Wang, Heqin Guan, Chunbo Chen, Qiufeng Cui, Xinwen Zhang, Xiuqing |
| description | This research investigates the impact of
polysaccharides (DOP) with different molecular weights on antioxidant effects, lifespan enhancement, and obesity reduction, utilizing both in vitro analyses and the
(
) model. Through a series of experiments-ranging from the extraction and modification of polysaccharides, Gel Permeation Chromatography (GPC), and analysis of composition to the evaluation of antioxidant capabilities, this study thoroughly examines DOP and its derivatives (DOP5, DOP15, DOP25) produced via H
O
-Fe
degradation. The results reveal a direct relationship between the molecular weight of polysaccharides and their bioactivity. Notably, DOP5, with its intermediate molecular weight, demonstrated superior antioxidant properties, significantly extended the lifespan, and improved the health of
Furthermore, DOP15 appeared to regulate lipid metabolism by affecting crucial lipid metabolism genes, including fat-4, fat-5, fat-6, sbp-1, and acs-2. These findings highlight the potential application of DOP derivatives as natural antioxidants and agents against obesity, contributing to the development of functional foods and dietary supplements. |
| doi_str_mv | 10.3390/foods13071040 |
| format | article |
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polysaccharides (DOP) with different molecular weights on antioxidant effects, lifespan enhancement, and obesity reduction, utilizing both in vitro analyses and the
(
) model. Through a series of experiments-ranging from the extraction and modification of polysaccharides, Gel Permeation Chromatography (GPC), and analysis of composition to the evaluation of antioxidant capabilities, this study thoroughly examines DOP and its derivatives (DOP5, DOP15, DOP25) produced via H
O
-Fe
degradation. The results reveal a direct relationship between the molecular weight of polysaccharides and their bioactivity. Notably, DOP5, with its intermediate molecular weight, demonstrated superior antioxidant properties, significantly extended the lifespan, and improved the health of
Furthermore, DOP15 appeared to regulate lipid metabolism by affecting crucial lipid metabolism genes, including fat-4, fat-5, fat-6, sbp-1, and acs-2. These findings highlight the potential application of DOP derivatives as natural antioxidants and agents against obesity, contributing to the development of functional foods and dietary supplements.</description><identifier>ISSN: 2304-8158</identifier><identifier>EISSN: 2304-8158</identifier><identifier>DOI: 10.3390/foods13071040</identifier><identifier>PMID: 38611346</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acids ; antioxidant ; Antioxidants ; Biological activity ; C. elegans ; Caenorhabditis elegans ; Dendrobium officinale ; Dietary supplements ; Fat metabolism ; Functional foods & nutraceuticals ; Gastrointestinal surgery ; Gel chromatography ; Hydrogen peroxide ; Investigations ; Life span ; Lipid metabolism ; Lipids ; Metabolism ; Molecular weight ; Obesity ; Polysaccharides ; Reagents ; Saccharides ; structural modification</subject><ispartof>Foods, 2024-03, Vol.13 (7), p.1040</ispartof><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-683a207ce6b54d3ecf772bbd4d91e193e96b52acd642718196d7d55e9f0c245b3</citedby><cites>FETCH-LOGICAL-c426t-683a207ce6b54d3ecf772bbd4d91e193e96b52acd642718196d7d55e9f0c245b3</cites><orcidid>0009-0007-9521-697X ; 0000-0003-4578-8359</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3037476729/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3037476729?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38611346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pang, Xiao</creatorcontrib><creatorcontrib>Wang, Heqin</creatorcontrib><creatorcontrib>Guan, Chunbo</creatorcontrib><creatorcontrib>Chen, Qiufeng</creatorcontrib><creatorcontrib>Cui, Xinwen</creatorcontrib><creatorcontrib>Zhang, Xiuqing</creatorcontrib><title>Impact of Molecular Weight Variations in Dendrobium officinale Polysaccharides on Antioxidant Activity and Anti-Obesity in Caenorhabditis elegans</title><title>Foods</title><addtitle>Foods</addtitle><description>This research investigates the impact of
polysaccharides (DOP) with different molecular weights on antioxidant effects, lifespan enhancement, and obesity reduction, utilizing both in vitro analyses and the
(
) model. Through a series of experiments-ranging from the extraction and modification of polysaccharides, Gel Permeation Chromatography (GPC), and analysis of composition to the evaluation of antioxidant capabilities, this study thoroughly examines DOP and its derivatives (DOP5, DOP15, DOP25) produced via H
O
-Fe
degradation. The results reveal a direct relationship between the molecular weight of polysaccharides and their bioactivity. Notably, DOP5, with its intermediate molecular weight, demonstrated superior antioxidant properties, significantly extended the lifespan, and improved the health of
Furthermore, DOP15 appeared to regulate lipid metabolism by affecting crucial lipid metabolism genes, including fat-4, fat-5, fat-6, sbp-1, and acs-2. These findings highlight the potential application of DOP derivatives as natural antioxidants and agents against obesity, contributing to the development of functional foods and dietary supplements.</description><subject>Acids</subject><subject>antioxidant</subject><subject>Antioxidants</subject><subject>Biological activity</subject><subject>C. elegans</subject><subject>Caenorhabditis elegans</subject><subject>Dendrobium officinale</subject><subject>Dietary supplements</subject><subject>Fat metabolism</subject><subject>Functional foods & nutraceuticals</subject><subject>Gastrointestinal surgery</subject><subject>Gel chromatography</subject><subject>Hydrogen peroxide</subject><subject>Investigations</subject><subject>Life span</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Metabolism</subject><subject>Molecular weight</subject><subject>Obesity</subject><subject>Polysaccharides</subject><subject>Reagents</subject><subject>Saccharides</subject><subject>structural modification</subject><issn>2304-8158</issn><issn>2304-8158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkU2P0zAQhiMEYlfLHrkiS1y4BPyVOD5WZYFKi5YDH8doYk9aV6ldbAfRn8E_xm2XFeCLrZnHj615q-o5o6-F0PTNGIJNTFDFqKSPqksuqKw71nSP_zpfVNcpbWlZmolO8KfVhehaxoRsL6tfq90eTCZhJB_DhGaeIJJv6NabTL5CdJBd8Ik4T96itzEMbt4VeHTGeZiQfArTIYExm8JaTCR4svDlzk9nwWeyMNn9cPlAwNtTo74bMB0LxbgE9CFuYLAuu0RwwjX49Kx6MsKU8Pp-v6q-vLv5vPxQ3969Xy0Xt7WRvM112wngVBlsh0ZagWZUig-DlVYzZFqgLg0OxraSK9Yx3Vplmwb1SA2XzSCuqtXZawNs-310O4iHPoDrT4UQ1z3E7MyEvWacl2lJSUUrqWTdWN7RjYLRaNnh0fXq7NrH8H3GlPudSwanCTyGOfWCik4Krbks6Mv_0G2YY5nliVJStYrrQtVnysSQUsTx4YOM9sfo-3-iL_yLe-s87NA-0H-CFr8BlGKqsA</recordid><startdate>20240328</startdate><enddate>20240328</enddate><creator>Pang, Xiao</creator><creator>Wang, Heqin</creator><creator>Guan, Chunbo</creator><creator>Chen, Qiufeng</creator><creator>Cui, Xinwen</creator><creator>Zhang, Xiuqing</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7T7</scope><scope>7X2</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>HCIFZ</scope><scope>M0K</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0009-0007-9521-697X</orcidid><orcidid>https://orcid.org/0000-0003-4578-8359</orcidid></search><sort><creationdate>20240328</creationdate><title>Impact of Molecular Weight Variations in Dendrobium officinale Polysaccharides on Antioxidant Activity and Anti-Obesity in Caenorhabditis elegans</title><author>Pang, Xiao ; Wang, Heqin ; Guan, Chunbo ; Chen, Qiufeng ; Cui, Xinwen ; Zhang, Xiuqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-683a207ce6b54d3ecf772bbd4d91e193e96b52acd642718196d7d55e9f0c245b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acids</topic><topic>antioxidant</topic><topic>Antioxidants</topic><topic>Biological activity</topic><topic>C. elegans</topic><topic>Caenorhabditis elegans</topic><topic>Dendrobium officinale</topic><topic>Dietary supplements</topic><topic>Fat metabolism</topic><topic>Functional foods & nutraceuticals</topic><topic>Gastrointestinal surgery</topic><topic>Gel chromatography</topic><topic>Hydrogen peroxide</topic><topic>Investigations</topic><topic>Life span</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Metabolism</topic><topic>Molecular weight</topic><topic>Obesity</topic><topic>Polysaccharides</topic><topic>Reagents</topic><topic>Saccharides</topic><topic>structural modification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pang, Xiao</creatorcontrib><creatorcontrib>Wang, Heqin</creatorcontrib><creatorcontrib>Guan, Chunbo</creatorcontrib><creatorcontrib>Chen, Qiufeng</creatorcontrib><creatorcontrib>Cui, Xinwen</creatorcontrib><creatorcontrib>Zhang, Xiuqing</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Agricultural Science Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Agriculture Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Directory of Open Access Journals</collection><jtitle>Foods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pang, Xiao</au><au>Wang, Heqin</au><au>Guan, Chunbo</au><au>Chen, Qiufeng</au><au>Cui, Xinwen</au><au>Zhang, Xiuqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Molecular Weight Variations in Dendrobium officinale Polysaccharides on Antioxidant Activity and Anti-Obesity in Caenorhabditis elegans</atitle><jtitle>Foods</jtitle><addtitle>Foods</addtitle><date>2024-03-28</date><risdate>2024</risdate><volume>13</volume><issue>7</issue><spage>1040</spage><pages>1040-</pages><issn>2304-8158</issn><eissn>2304-8158</eissn><abstract>This research investigates the impact of
polysaccharides (DOP) with different molecular weights on antioxidant effects, lifespan enhancement, and obesity reduction, utilizing both in vitro analyses and the
(
) model. Through a series of experiments-ranging from the extraction and modification of polysaccharides, Gel Permeation Chromatography (GPC), and analysis of composition to the evaluation of antioxidant capabilities, this study thoroughly examines DOP and its derivatives (DOP5, DOP15, DOP25) produced via H
O
-Fe
degradation. The results reveal a direct relationship between the molecular weight of polysaccharides and their bioactivity. Notably, DOP5, with its intermediate molecular weight, demonstrated superior antioxidant properties, significantly extended the lifespan, and improved the health of
Furthermore, DOP15 appeared to regulate lipid metabolism by affecting crucial lipid metabolism genes, including fat-4, fat-5, fat-6, sbp-1, and acs-2. These findings highlight the potential application of DOP derivatives as natural antioxidants and agents against obesity, contributing to the development of functional foods and dietary supplements.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38611346</pmid><doi>10.3390/foods13071040</doi><orcidid>https://orcid.org/0009-0007-9521-697X</orcidid><orcidid>https://orcid.org/0000-0003-4578-8359</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Foods, 2024-03, Vol.13 (7), p.1040 |
| issn | 2304-8158 2304-8158 |
| language | eng |
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| source | Open Access: PubMed Central; Publicly Available Content Database (Proquest) (PQ_SDU_P3) |
| subjects | Acids antioxidant Antioxidants Biological activity C. elegans Caenorhabditis elegans Dendrobium officinale Dietary supplements Fat metabolism Functional foods & nutraceuticals Gastrointestinal surgery Gel chromatography Hydrogen peroxide Investigations Life span Lipid metabolism Lipids Metabolism Molecular weight Obesity Polysaccharides Reagents Saccharides structural modification |
| title | Impact of Molecular Weight Variations in Dendrobium officinale Polysaccharides on Antioxidant Activity and Anti-Obesity in Caenorhabditis elegans |
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