Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient

WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient's lung by electron microscopy. WUPyV was detected in the lung and other t...

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Bibliographic Details
Published in:Emerging infectious diseases 2016-01, Vol.22 (1), p.24-31
Main Authors: Siebrasse, Erica A, Nguyen, Nang L, Willby, Melisa J, Erdman, Dean D, Menegus, Marilyn A, Wang, David
Format: Article
Language:English
Subjects:
Bone marrow
Bone Marrow Transplantation
Child, Preschool
epithelial cells
Female
Health aspects
Humans
immunosuppression
Lung - virology
Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient
Organ transplant recipients
Physiological aspects
Polyoma virus
Polyomavirus - isolation & purification
Polyomavirus Infections - diagnosis
Respiratory Tract Infections - virology
transplant
Transplant Recipients
Transplantation
tropism
viruses
WU polyomavirus
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Summary:WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient's lung by electron microscopy. WUPyV was detected in the lung and other tissues by real-time quantitative PCR and identified in the lung and trachea by immunohistochemistry. A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2201.151384