Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28

Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo neuroinflammation in individuals with amyotrophic lateral sclerosis using [(11)...

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Bibliographic Details
Published in:NeuroImage clinical 2015-01, Vol.7 (C), p.409-414
Main Authors: Zürcher, Nicole R, Loggia, Marco L, Lawson, Robert, Chonde, Daniel B, Izquierdo-Garcia, David, Yasek, Julia E, Akeju, Oluwaseun, Catana, Ciprian, Rosen, Bruce R, Cudkowicz, Merit E, Hooker, Jacob M, Atassi, Nazem
Format: Article
Language:English
Subjects:
[11C]PBR-28
Acetamides
Adult
Aged
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - diagnostic imaging
Brain - diagnostic imaging
Carbon Radioisotopes
Female
Humans
Male
Microglia
Middle Aged
Motor cortex
Neuroglia - diagnostic imaging
Neuroinflammation
Positron emission tomography
Positron-Emission Tomography - methods
Pyridines
Radiographic Image Interpretation, Computer-Assisted
Radiopharmaceuticals
Regular
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Summary:Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo neuroinflammation in individuals with amyotrophic lateral sclerosis using [(11)C]-PBR28 positron emission tomography. Ten patients with amyotrophic lateral sclerosis (seven males, three females, 38-68 years) and ten age- and [(11)C]-PBR28 binding affinity-matched healthy volunteers (six males, four females, 33-65 years) completed a positron emission tomography scan. Standardized uptake values were calculated from 60 to 90 min post-injection and normalized to whole brain mean. Voxel-wise analysis showed increased binding in the motor cortices and corticospinal tracts in patients with amyotrophic lateral sclerosis compared to healthy controls (p FWE 
ISSN:2213-1582
2213-1582
DOI:10.1016/j.nicl.2015.01.009