Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28

Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo neuroinflammation in individuals with amyotrophic lateral sclerosis using [(11)...

Full description

Saved in:
Bibliographic Details
Published in:NeuroImage clinical 2015-01, Vol.7 (C), p.409-414
Main Authors: Zürcher, Nicole R, Loggia, Marco L, Lawson, Robert, Chonde, Daniel B, Izquierdo-Garcia, David, Yasek, Julia E, Akeju, Oluwaseun, Catana, Ciprian, Rosen, Bruce R, Cudkowicz, Merit E, Hooker, Jacob M, Atassi, Nazem
Format: Article
Language:English
Subjects:
[11C]PBR-28
Acetamides
Adult
Aged
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - diagnostic imaging
Brain - diagnostic imaging
Carbon Radioisotopes
Female
Humans
Male
Microglia
Middle Aged
Motor cortex
Neuroglia - diagnostic imaging
Neuroinflammation
Positron emission tomography
Positron-Emission Tomography - methods
Pyridines
Radiographic Image Interpretation, Computer-Assisted
Radiopharmaceuticals
Regular
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c468t-75ea4fa93b57d82d7c7d091d9b6e650c669119c245d57fcf230217b38465f2833
cites cdi_FETCH-LOGICAL-c468t-75ea4fa93b57d82d7c7d091d9b6e650c669119c245d57fcf230217b38465f2833
container_end_page 414
container_issue C
container_start_page 409
container_title NeuroImage clinical
container_volume 7
creator Zürcher, Nicole R
Loggia, Marco L
Lawson, Robert
Chonde, Daniel B
Izquierdo-Garcia, David
Yasek, Julia E
Akeju, Oluwaseun
Catana, Ciprian
Rosen, Bruce R
Cudkowicz, Merit E
Hooker, Jacob M
Atassi, Nazem
description Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo neuroinflammation in individuals with amyotrophic lateral sclerosis using [(11)C]-PBR28 positron emission tomography. Ten patients with amyotrophic lateral sclerosis (seven males, three females, 38-68 years) and ten age- and [(11)C]-PBR28 binding affinity-matched healthy volunteers (six males, four females, 33-65 years) completed a positron emission tomography scan. Standardized uptake values were calculated from 60 to 90 min post-injection and normalized to whole brain mean. Voxel-wise analysis showed increased binding in the motor cortices and corticospinal tracts in patients with amyotrophic lateral sclerosis compared to healthy controls (p FWE 
doi_str_mv 10.1016/j.nicl.2015.01.009
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_913971f2f82b41c3829338f4a02c0e44</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_913971f2f82b41c3829338f4a02c0e44</doaj_id><sourcerecordid>1657318826</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-75ea4fa93b57d82d7c7d091d9b6e650c669119c245d57fcf230217b38465f2833</originalsourceid><addsrcrecordid>eNpVkV9rFDEUxQdRbKn9Aj7IPNaHGXPzPz4IulRdKFiKPomETCbZzTI7WZPZlX77Zrq1tHnJJffcX5JzquotoBYQ8A-bdgx2aDEC1iJoEVIvqlOMgTTAJH75pD6pznPeoLIkQoLz19UJZlwygeRpNS5Hm5zJrq_DWB_CIdarIZihNnYKBzOFOM6NXancOOX6X5jWtdnexinF3TrYejCTS0Wf7eBSzCF_rE3OLs_Ee_HvC4D3iz_N9ZcbLN9Ur7wZsjt_2M-qX18vfy6-N1c_vi0Xn68aS7mcGsGcod4o0jHRS9wLK3qkoFcdd5why7kCUBZT1jPhrccEYRAdkZQzjyUhZ9XyyO2j2ehdCluTbnU0Qd8fxLTSJk3FQKcVECXAYy9xR8ESiRUh0lODsEWO0sL6dGTt9t3W9bb4UD78DPq8M4a1XsWDpgSQIrgALh4AKf7duzzpbcjWDYMZXdxnDZwJAlJiXqT4KLXFy5ycf7wGkJ5z1xs9567n3DUCXXIvQ--ePvBx5H_K5A4K7qmS</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1657318826</pqid></control><display><type>article</type><title>Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28</title><source>ScienceDirect</source><source>PubMed Central Free</source><creator>Zürcher, Nicole R ; Loggia, Marco L ; Lawson, Robert ; Chonde, Daniel B ; Izquierdo-Garcia, David ; Yasek, Julia E ; Akeju, Oluwaseun ; Catana, Ciprian ; Rosen, Bruce R ; Cudkowicz, Merit E ; Hooker, Jacob M ; Atassi, Nazem</creator><creatorcontrib>Zürcher, Nicole R ; Loggia, Marco L ; Lawson, Robert ; Chonde, Daniel B ; Izquierdo-Garcia, David ; Yasek, Julia E ; Akeju, Oluwaseun ; Catana, Ciprian ; Rosen, Bruce R ; Cudkowicz, Merit E ; Hooker, Jacob M ; Atassi, Nazem</creatorcontrib><description>Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo neuroinflammation in individuals with amyotrophic lateral sclerosis using [(11)C]-PBR28 positron emission tomography. Ten patients with amyotrophic lateral sclerosis (seven males, three females, 38-68 years) and ten age- and [(11)C]-PBR28 binding affinity-matched healthy volunteers (six males, four females, 33-65 years) completed a positron emission tomography scan. Standardized uptake values were calculated from 60 to 90 min post-injection and normalized to whole brain mean. Voxel-wise analysis showed increased binding in the motor cortices and corticospinal tracts in patients with amyotrophic lateral sclerosis compared to healthy controls (p FWE &lt; 0.05). Region of interest analysis revealed increased [(11)C]-PBR28 binding in the precentral gyrus in patients (normalized standardized uptake value = 1.15) compared to controls (1.03, p &lt; 0.05). In patients those values were positively correlated with upper motor neuron burden scores (r = 0.69, p &lt; 0.05), and negatively correlated with the amyotrophic lateral sclerosis functional rating scale (r = -0.66, p &lt; 0.05). Increased in vivo glial activation in motor cortices, that correlates with phenotype, complements previous histopathological reports. Further studies will determine the role of [(11)C]-PBR28 as a marker of treatments that target neuroinflammation.</description><identifier>ISSN: 2213-1582</identifier><identifier>EISSN: 2213-1582</identifier><identifier>DOI: 10.1016/j.nicl.2015.01.009</identifier><identifier>PMID: 25685708</identifier><language>eng</language><publisher>Netherlands: Elsevier</publisher><subject>[11C]PBR-28 ; Acetamides ; Adult ; Aged ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - diagnostic imaging ; Brain - diagnostic imaging ; Carbon Radioisotopes ; Female ; Humans ; Male ; Microglia ; Middle Aged ; Motor cortex ; Neuroglia - diagnostic imaging ; Neuroinflammation ; Positron emission tomography ; Positron-Emission Tomography - methods ; Pyridines ; Radiographic Image Interpretation, Computer-Assisted ; Radiopharmaceuticals ; Regular</subject><ispartof>NeuroImage clinical, 2015-01, Vol.7 (C), p.409-414</ispartof><rights>2015 The Authors. Published by Elsevier Inc. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-75ea4fa93b57d82d7c7d091d9b6e650c669119c245d57fcf230217b38465f2833</citedby><cites>FETCH-LOGICAL-c468t-75ea4fa93b57d82d7c7d091d9b6e650c669119c245d57fcf230217b38465f2833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310932/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310932/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25685708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zürcher, Nicole R</creatorcontrib><creatorcontrib>Loggia, Marco L</creatorcontrib><creatorcontrib>Lawson, Robert</creatorcontrib><creatorcontrib>Chonde, Daniel B</creatorcontrib><creatorcontrib>Izquierdo-Garcia, David</creatorcontrib><creatorcontrib>Yasek, Julia E</creatorcontrib><creatorcontrib>Akeju, Oluwaseun</creatorcontrib><creatorcontrib>Catana, Ciprian</creatorcontrib><creatorcontrib>Rosen, Bruce R</creatorcontrib><creatorcontrib>Cudkowicz, Merit E</creatorcontrib><creatorcontrib>Hooker, Jacob M</creatorcontrib><creatorcontrib>Atassi, Nazem</creatorcontrib><title>Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28</title><title>NeuroImage clinical</title><addtitle>Neuroimage Clin</addtitle><description>Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo neuroinflammation in individuals with amyotrophic lateral sclerosis using [(11)C]-PBR28 positron emission tomography. Ten patients with amyotrophic lateral sclerosis (seven males, three females, 38-68 years) and ten age- and [(11)C]-PBR28 binding affinity-matched healthy volunteers (six males, four females, 33-65 years) completed a positron emission tomography scan. Standardized uptake values were calculated from 60 to 90 min post-injection and normalized to whole brain mean. Voxel-wise analysis showed increased binding in the motor cortices and corticospinal tracts in patients with amyotrophic lateral sclerosis compared to healthy controls (p FWE &lt; 0.05). Region of interest analysis revealed increased [(11)C]-PBR28 binding in the precentral gyrus in patients (normalized standardized uptake value = 1.15) compared to controls (1.03, p &lt; 0.05). In patients those values were positively correlated with upper motor neuron burden scores (r = 0.69, p &lt; 0.05), and negatively correlated with the amyotrophic lateral sclerosis functional rating scale (r = -0.66, p &lt; 0.05). Increased in vivo glial activation in motor cortices, that correlates with phenotype, complements previous histopathological reports. Further studies will determine the role of [(11)C]-PBR28 as a marker of treatments that target neuroinflammation.</description><subject>[11C]PBR-28</subject><subject>Acetamides</subject><subject>Adult</subject><subject>Aged</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - diagnostic imaging</subject><subject>Brain - diagnostic imaging</subject><subject>Carbon Radioisotopes</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Microglia</subject><subject>Middle Aged</subject><subject>Motor cortex</subject><subject>Neuroglia - diagnostic imaging</subject><subject>Neuroinflammation</subject><subject>Positron emission tomography</subject><subject>Positron-Emission Tomography - methods</subject><subject>Pyridines</subject><subject>Radiographic Image Interpretation, Computer-Assisted</subject><subject>Radiopharmaceuticals</subject><subject>Regular</subject><issn>2213-1582</issn><issn>2213-1582</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkV9rFDEUxQdRbKn9Aj7IPNaHGXPzPz4IulRdKFiKPomETCbZzTI7WZPZlX77Zrq1tHnJJffcX5JzquotoBYQ8A-bdgx2aDEC1iJoEVIvqlOMgTTAJH75pD6pznPeoLIkQoLz19UJZlwygeRpNS5Hm5zJrq_DWB_CIdarIZihNnYKBzOFOM6NXancOOX6X5jWtdnexinF3TrYejCTS0Wf7eBSzCF_rE3OLs_Ee_HvC4D3iz_N9ZcbLN9Ur7wZsjt_2M-qX18vfy6-N1c_vi0Xn68aS7mcGsGcod4o0jHRS9wLK3qkoFcdd5why7kCUBZT1jPhrccEYRAdkZQzjyUhZ9XyyO2j2ehdCluTbnU0Qd8fxLTSJk3FQKcVECXAYy9xR8ESiRUh0lODsEWO0sL6dGTt9t3W9bb4UD78DPq8M4a1XsWDpgSQIrgALh4AKf7duzzpbcjWDYMZXdxnDZwJAlJiXqT4KLXFy5ycf7wGkJ5z1xs9567n3DUCXXIvQ--ePvBx5H_K5A4K7qmS</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Zürcher, Nicole R</creator><creator>Loggia, Marco L</creator><creator>Lawson, Robert</creator><creator>Chonde, Daniel B</creator><creator>Izquierdo-Garcia, David</creator><creator>Yasek, Julia E</creator><creator>Akeju, Oluwaseun</creator><creator>Catana, Ciprian</creator><creator>Rosen, Bruce R</creator><creator>Cudkowicz, Merit E</creator><creator>Hooker, Jacob M</creator><creator>Atassi, Nazem</creator><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150101</creationdate><title>Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28</title><author>Zürcher, Nicole R ; Loggia, Marco L ; Lawson, Robert ; Chonde, Daniel B ; Izquierdo-Garcia, David ; Yasek, Julia E ; Akeju, Oluwaseun ; Catana, Ciprian ; Rosen, Bruce R ; Cudkowicz, Merit E ; Hooker, Jacob M ; Atassi, Nazem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-75ea4fa93b57d82d7c7d091d9b6e650c669119c245d57fcf230217b38465f2833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>[11C]PBR-28</topic><topic>Acetamides</topic><topic>Adult</topic><topic>Aged</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - diagnostic imaging</topic><topic>Brain - diagnostic imaging</topic><topic>Carbon Radioisotopes</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Microglia</topic><topic>Middle Aged</topic><topic>Motor cortex</topic><topic>Neuroglia - diagnostic imaging</topic><topic>Neuroinflammation</topic><topic>Positron emission tomography</topic><topic>Positron-Emission Tomography - methods</topic><topic>Pyridines</topic><topic>Radiographic Image Interpretation, Computer-Assisted</topic><topic>Radiopharmaceuticals</topic><topic>Regular</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zürcher, Nicole R</creatorcontrib><creatorcontrib>Loggia, Marco L</creatorcontrib><creatorcontrib>Lawson, Robert</creatorcontrib><creatorcontrib>Chonde, Daniel B</creatorcontrib><creatorcontrib>Izquierdo-Garcia, David</creatorcontrib><creatorcontrib>Yasek, Julia E</creatorcontrib><creatorcontrib>Akeju, Oluwaseun</creatorcontrib><creatorcontrib>Catana, Ciprian</creatorcontrib><creatorcontrib>Rosen, Bruce R</creatorcontrib><creatorcontrib>Cudkowicz, Merit E</creatorcontrib><creatorcontrib>Hooker, Jacob M</creatorcontrib><creatorcontrib>Atassi, Nazem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals(OpenAccess)</collection><jtitle>NeuroImage clinical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zürcher, Nicole R</au><au>Loggia, Marco L</au><au>Lawson, Robert</au><au>Chonde, Daniel B</au><au>Izquierdo-Garcia, David</au><au>Yasek, Julia E</au><au>Akeju, Oluwaseun</au><au>Catana, Ciprian</au><au>Rosen, Bruce R</au><au>Cudkowicz, Merit E</au><au>Hooker, Jacob M</au><au>Atassi, Nazem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28</atitle><jtitle>NeuroImage clinical</jtitle><addtitle>Neuroimage Clin</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>7</volume><issue>C</issue><spage>409</spage><epage>414</epage><pages>409-414</pages><issn>2213-1582</issn><eissn>2213-1582</eissn><abstract>Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo neuroinflammation in individuals with amyotrophic lateral sclerosis using [(11)C]-PBR28 positron emission tomography. Ten patients with amyotrophic lateral sclerosis (seven males, three females, 38-68 years) and ten age- and [(11)C]-PBR28 binding affinity-matched healthy volunteers (six males, four females, 33-65 years) completed a positron emission tomography scan. Standardized uptake values were calculated from 60 to 90 min post-injection and normalized to whole brain mean. Voxel-wise analysis showed increased binding in the motor cortices and corticospinal tracts in patients with amyotrophic lateral sclerosis compared to healthy controls (p FWE &lt; 0.05). Region of interest analysis revealed increased [(11)C]-PBR28 binding in the precentral gyrus in patients (normalized standardized uptake value = 1.15) compared to controls (1.03, p &lt; 0.05). In patients those values were positively correlated with upper motor neuron burden scores (r = 0.69, p &lt; 0.05), and negatively correlated with the amyotrophic lateral sclerosis functional rating scale (r = -0.66, p &lt; 0.05). Increased in vivo glial activation in motor cortices, that correlates with phenotype, complements previous histopathological reports. Further studies will determine the role of [(11)C]-PBR28 as a marker of treatments that target neuroinflammation.</abstract><cop>Netherlands</cop><pub>Elsevier</pub><pmid>25685708</pmid><doi>10.1016/j.nicl.2015.01.009</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2213-1582
ispartof NeuroImage clinical, 2015-01, Vol.7 (C), p.409-414
issn 2213-1582
2213-1582
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_913971f2f82b41c3829338f4a02c0e44
source ScienceDirect; PubMed Central Free
subjects [11C]PBR-28
Acetamides
Adult
Aged
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - diagnostic imaging
Brain - diagnostic imaging
Carbon Radioisotopes
Female
Humans
Male
Microglia
Middle Aged
Motor cortex
Neuroglia - diagnostic imaging
Neuroinflammation
Positron emission tomography
Positron-Emission Tomography - methods
Pyridines
Radiographic Image Interpretation, Computer-Assisted
Radiopharmaceuticals
Regular
title Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T04%3A02%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20in%20vivo%20glial%20activation%20in%20patients%20with%20amyotrophic%20lateral%20sclerosis:%20assessed%20with%20%5B(11)C%5D-PBR28&rft.jtitle=NeuroImage%20clinical&rft.au=Z%C3%BCrcher,%20Nicole%20R&rft.date=2015-01-01&rft.volume=7&rft.issue=C&rft.spage=409&rft.epage=414&rft.pages=409-414&rft.issn=2213-1582&rft.eissn=2213-1582&rft_id=info:doi/10.1016/j.nicl.2015.01.009&rft_dat=%3Cproquest_doaj_%3E1657318826%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c468t-75ea4fa93b57d82d7c7d091d9b6e650c669119c245d57fcf230217b38465f2833%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1657318826&rft_id=info:pmid/25685708&rfr_iscdi=true