Anti-Diabetic Effects of Different Phenolic-Rich Fractions from Rhus Chinensis Mill. Fruits in vitro

This study investigated the inhibitory effects of the Ethanol Extract (EE), Free Phenolic (TF), Esterified Phenolic (TE) and Insoluble-bound Phenolic (TI) from Rhus chinensis Mill. fruits on α -glucosidase, Dipeptidyl Peptidase-4 (DPP-IV), and the formation of Advanced Glycation End (AGE) products....

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Bibliographic Details
Published in:eFood (Amsterdam) 2021-02, Vol.2 (1), p.37-46
Main Authors: Liu, Xiaojing, Fu, Yishan, Ma, Qian, Yi, Junjie, Cai, Shengbao
Format: Article
Language:English
Subjects:
Advanced glycosylation end products
AGEs inhibition
Chinese sumac
Chronic illnesses
Correlation analysis
Diabetes
Diabetes mellitus
Diabetic neuropathy
DPP-IV inhibition
Esterification
Ethanol
Flavonoids
Fruits
Functional foods & nutraceuticals
Glucose
Glucosidase
Hyperglycemia
interaction
Pathogenesis
Phenolic compounds
Phenols
Physiology
Proteins
Protocatechuic acid
Quercetin
Special Issue
Synergistic effect
α-glucosidase inhibition
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Summary:This study investigated the inhibitory effects of the Ethanol Extract (EE), Free Phenolic (TF), Esterified Phenolic (TE) and Insoluble-bound Phenolic (TI) from Rhus chinensis Mill. fruits on α -glucosidase, Dipeptidyl Peptidase-4 (DPP-IV), and the formation of Advanced Glycation End (AGE) products. Results showed that the TF had the strongest inhibition against α -glucosidase and DPP-IV with IC 50 of 0.56 ± 0.04 and 66.08 ± 1.36 μg/mL, respectively ( p < 0.05). TI exhibited the strongest inhibitory effect on the formation of AGEs with IC 50 of 0.43 ± 0.03 mg/mL ( p < 0.05). Two major compounds (myricetin-3- O- rhamnoside and quercetin-3- O -rhamnoside) showed additive or synergistic effects on α -glucosidase inhibition, while displayed antagonistic effect on DPP-IV inhibition. Correlation analysis indicated that myricetin-3- O -(6″-galloyl) glycoside and myricetin O -gallate contributed significantly on α -glucosidase inhibition, while di- O -galloyl-glucoside and its isomer may contribute remarkably toward DPP-IV inhibition. Protocatechuic acid and myricetin-3- O -rhamnoside showed a positive correlation with the suppression of AGEs formation. Those results may provide some scientific information for exploring R. chinensis fruits as nutraceuticals and/or functional foods to prevent or improve diabetes.
ISSN:2666-3066
2666-3066
DOI:10.2991/efood.k.210222.002