Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis

Bone homeostasis, which involves formation and resorption, is an important process for maintaining adequate bone mass in humans. Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and bone loss, leading to joint destruction and deformity, and is a representative disease...

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Bibliographic Details
Published in:Journal of immunology research 2014-01, Vol.2014 (2014), p.1-15
Main Authors: Park, Sung-Hwan, Yang, Chul Woo, Kim, Kyoung Woon, Jung, Seung Min, Ju, Ji Hyeon
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - pathology
Bone and Bones - immunology
Bone and Bones - metabolism
Bone and Bones - pathology
Cytokines
Cytokines - immunology
Cytokines - metabolism
Homeostasis
Humans
Immune system
Immune System - immunology
Immune System - metabolism
Immune System - pathology
Immunology
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
Internal medicine
Ligands
Medical research
Medicine
Models, Immunological
Osteoblasts - immunology
Osteoblasts - metabolism
Osteoclasts - immunology
Osteoclasts - metabolism
Pathogenesis
Review
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Summary:Bone homeostasis, which involves formation and resorption, is an important process for maintaining adequate bone mass in humans. Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and bone loss, leading to joint destruction and deformity, and is a representative disease of disrupted bone homeostasis. The bone loss and joint destruction are mediated by immunological insults by proinflammatory cytokines and various immune cells. The connection between bone and immunity has been intensely studied and comprises the emerging field of osteoimmunology. Osteoimmunology is an interdisciplinary science investigating the interplay between the skeletal and the immune systems. The main contributors in osteoimmunology are the bone effector cells, such as osteoclasts or osteoblasts, and the immune cells, particularly lymphocytes and monocytes. Physiologically, osteoclasts originate from immune cells, and immune cells regulate osteoblasts and vice versa. Pathological conditions such as RA might affect these interactions, thereby altering bone homeostasis, resulting in the unfavorable outcome of bone destruction. In this review, we describe the osteoclastogenic roles of the proinflammatory cytokines and immune cells that are important in the pathophysiology of RA.
ISSN:2314-8861
2314-7156
DOI:10.1155/2014/263625