Glutathione S-transferase M1 and T1 genes deletion polymorphisms and blood pressure control among treated essential hypertensive patients in Burkina Faso

Glutathione S-transferases have been associated with experimental resistance to some drugs. The present study investigated the factors associated with blood pressure control in patients with essential hypertension, especially the role of GSTT1 and GSTM1 genes polymorphisms. This cross-sectional stud...

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Published in:BMC research notes 2021-06, Vol.14 (1), p.244-244, Article 244
Main Authors: Sombié, Herman Karim, Tchelougou, Daméhan, Ouattara, Abdoul Karim, Kologo, Jonas Koudougou, Sorgho, Pegdwendé Abel, Somda, Dogfunianalo, Yaméogo, Sakinata, Zongo, Arsène Wendpagnangdé, Kiendrebeogo, Isabelle Touwendpoulimdé, Adoko, Enagnon Tiémoko Herman Donald, Yonli, Albert Théophane, Djigma, Florencia Wendkuuni, Zabsonré, Patrice, Millogo, Hassanata, Simporé, Jacques
Format: Article
Language:English
Subjects:
Alcohol
Antihypertensives
Bioavailability
Blood Pressure
Blood pressure control
Burkina Faso
Care and treatment
Case-Control Studies
Cross-Sectional Studies
Diagnosis
Drug resistance
Drugs
Essential hypertension
Gene polymorphism
Genes
Genetic polymorphisms
Genetic Predisposition to Disease
Genotype
Glutathione transferase
Glutathione Transferase - genetics
GSTM1
GSTM1 gene
GSTM1 protein
GSTT1
GSTT1 protein
Health aspects
Humans
Hypertension
Hypertension - drug therapy
Hypertension - genetics
Patients
Polymorphism, Genetic
Population
Questionnaires
Regulation
Research Note
Sociodemographics
Statistical analysis
Citations: Items that this one cites
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Summary:Glutathione S-transferases have been associated with experimental resistance to some drugs. The present study investigated the factors associated with blood pressure control in patients with essential hypertension, especially the role of GSTT1 and GSTM1 genes polymorphisms. This cross-sectional study in Burkina Faso consisted of 200 patients with essential hypertension and under treatment. In the present study, 57.5% (115/200) of patients had their hypertension under control. No statistically significant difference was found between controlled and uncontrolled groups for anthropometric and biochemical parameters as well as for GSTT1 or GSTM1 gene polymorphisms (all p > 0.05). Current alcohol consumption (OR = 3.04; CI 1.88-6.13; p 
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-021-05658-w